{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T12:46:24Z","timestamp":1759063584384},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"vor","delay-in-days":9105,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A clinical and serological study was performed on 267 of 636 volunteers vaccinated against Argentine hemorrhagic fever with the XJCl<jats:sub>3<\/jats:sub> attenuated strain of Junin virus seven to nine years earlier, in order to determine their long\u2010term evolution.<\/jats:p><jats:p>This study included a clinical examination, a chest roentgenogram, an electrocardiogram, and the following laboratory determinations: white and red cell count, number of platelets, hematocrit, hemoglobin, sedimentation rate (Katz index), urea, nitrogen, glucose concentration, cholesterol, GOT, GPT, gamma GT, alkaline phosphatase, cholinesterase, and total bilirubin. Neutralization reactions were performed to determine persistence of antibody levels.<\/jats:p><jats:p>All clinical and laboratory findings were within normal limits, excluding a long\u2010term pathology attributable to the virus. Of 165 tested sera, 153 (90.3%) had detectable levels of neutralizing antibodies, and the rest had no antibodies after this time.<\/jats:p><jats:p>Although these people live in the endemic area, it is considered that only the 9% that had increased antibody levels had suffered a reinfection during the seven\u2010 to nine\u2010year period, which acted as a booster. This figure approximately corresponds to the subclinical infection value found in the region. In the rest, the persistence of antibodies is attributed to the immunization achieved with the vaccine employed.<\/jats:p>","DOI":"10.1002\/jmv.1890070307","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T02:11:45Z","timestamp":1172801505000},"page":"227-232","source":"Crossref","is-referenced-by-count":8,"title":["Immunogenitity of A\/USSR (H1N1) subunit vaccine in unprimed young adults"],"prefix":"10.1002","volume":"7","author":[{"given":"H\u00e9ctor A.","family":"Ruggiero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemente","family":"Magnoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda B.","family":"De Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor A.","family":"Milani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Perez","family":"Izquierdo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor L.","family":"Milani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elba Laura","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"279","article-title":"Estudios inmunol\u00f3gicos con cobayos inoculados con virus inactivados por formol","volume":"27","author":"Oro JG Barrera","year":"1967","journal-title":"Medicina (Buenos Aires)"},{"key":"e_1_2_1_3_1","first-page":"69","article-title":"Anticuerpos contra virus Jun\u00edn y LCM en casos presuntivos de fiebre hemorr\u00e1gica argentina","volume":"37","author":"Oro JG Barrera","year":"1977","journal-title":"Medicina (Buenos Aires)"},{"key":"e_1_2_1_4_1","first-page":"271","article-title":"Infecti\u00f3n experimental del cobayo con virus Jun\u00edn. 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In Lennete EH Schmidt NJ (eds): \u201cDiagnostic Procedures for Viral and Rickettsial Infections.\u201d New York p52."},{"key":"e_1_2_1_7_1","first-page":"567","article-title":"Clinical and epidemiological patterns of Argentine hemorrhagic fever","volume":"52","author":"Maiztegui JI","year":"1975","journal-title":"Bull WHO"},{"key":"e_1_2_1_8_1","first-page":"171","article-title":"Estudio hematol\u00f3gico en cobayos infectados con virus Jun\u00edn cepa XJ y cepa XJC13","volume":"29","author":"Nota NR","year":"1969","journal-title":"Medicina (Buenos Aires)"},{"key":"e_1_2_1_9_1","first-page":"132","article-title":"Fiebre hemorr\u00e1gica argentina, vacunaci\u00f3n con virus Jun\u00edn inactivado","volume":"21","author":"Parodi AS","year":"1965","journal-title":"Ciencia e Investigaci\u00f3n"},{"issue":"1","key":"e_1_2_1_10_1","first-page":"3","article-title":"Inmunizaci\u00f3n contra la fiebre hemorr\u00e1gica argentina con una cepa atenuada de virus Jun\u00edn. IV. 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