{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:40:28Z","timestamp":1768012828980,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,2,24]],"date-time":"2008-02-24T00:00:00Z","timestamp":1203811200000},"content-version":"vor","delay-in-days":9915,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An enzyme\u2010linked immunosorbent assay for the demonstration of mumps immunoglobulin G (IgG ELISA) and immunoglobulin M antibodies (IgM ELISA) in serum was compared with complement fixation (CF), hemagglutination inhibition (HI), and hemolysis\u2010in\u2010gel (HIG) tests. The antibody levels measured by IgG ELISA had a high positive correlation with the CF and HIG tests, whereas only a moderate correlation was found between IgG ELISA and HI. Similar patterns of antibody response were observed with IgG ELISA, CF, and HIG: the antibody titres increased rapidly after the onset of symptoms and reached the maximal values in about three weeks. The HI antibodies developed more slowly during the first week of disease, after which the titres increased rapidly up to the fourth week. IgM antibodies measured by ELISA developed soon after onset of symptoms; most patients had IgM antibodies from the second day, and the highest titres were reached within the first week. The antibody response in mumps parotitis did not differ from that in mumps meningitis\/encephalitis, while relatively higher antibody titres were found in patients with orchitis\/epididymitis. The diagnostic efficiencies of the methods were compared with serum specimens from 33 patients who had a serologically verified mumps infection by at least one of the five methods used (rising antibody titres in paired sera or detectable IgM): IgM ELISA detected all 33 cases, IgG ELISA 29, HIG 28, HI 23, and CF 13. In 27 cases, IgM antibodies were already present in the acute phase serum specimens. It was concluded that mumps IgM ELISA is a more rapid and sensitive means for the serological diagnosis of mumps infection than the conventional tests.<\/jats:p>","DOI":"10.1002\/jmv.1890080207","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T02:20:36Z","timestamp":1172802036000},"page":"131-142","source":"Crossref","is-referenced-by-count":44,"title":["Mumps\u2010specific immunoglobulin M and G antibodies in natural mumps infection as measured by enzyme\u2010linked immunosorbent assay"],"prefix":"10.1002","volume":"8","author":[{"given":"Pentti","family":"Ukkonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Penttinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marja\u2010Liisa","family":"Granstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4049\/jimmunol.104.1.86","article-title":"Development and duration of mumps fluorescent antibodies in various immunoglobulin fractions of human serum","volume":"104","author":"Brown GC","year":"1970","journal-title":"Journal of Immunology"},{"key":"e_1_2_1_3_1","first-page":"33","volume-title":"Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections","author":"Hopps HE","year":"1979"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-160-40451"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02121756"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1128\/jcm.5.3.346-352.1977","article-title":"New tests for characterization of mumps virus antibodies: Hemolysis inhibition, single radial immunodiffusion with immobilized virions, and mixed hemadsorption","volume":"5","author":"Norrby E","year":"1977","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/oxfordjournals.aje.a120882","article-title":"Mumps vaccination in the Finnish Defense Forces","volume":"88","author":"Penttinen K","year":"1968","journal-title":"American Journal of Epidemiology"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/142.2.250"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/01971528008055779"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","unstructured":"UkkonenP PenttinenK(1981): Immunity induced by formalin\u2010inactivated mumps virus vaccine: Suppression of IgM antibody response. Journal of Infectious Diseases 144 (in press).","DOI":"10.1093\/infdis\/144.5.496"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1128\/jcm.11.4.319-323.1980","article-title":"Enzyme\u2010linked immunosorbent assay for mumps and parainfluenza type 1 immunoglobulin G and immunoglobulin M antibodies","volume":"11","author":"Ukkonen P","year":"1980","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01317868"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890080207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890080207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T01:33:59Z","timestamp":1699839239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890080207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/jmv.1890080207"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890080207","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}