{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T02:40:14Z","timestamp":1778035214564,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":9111,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunoglobulin G (IgG) and M (IgM) antibodies against mumps virus were measured by an enzyme\u2010linked immunosorbent assay (ELISA) in the serum and cerebrospinal fluid (CSF) specimens of patients with mumps meningitis. The CSF IgG antibodies correlated well with the respective antibody titers in serum. On the contrary, in only about half of the patients a moderate correlation was found between the CSF and serum IgM antibody titers, while the other patients did not have detectable mumps IgM antibodies in CSF irrespective of intermediate to high titers in serum. Two different immunologic mechanisms may be involved in these two groups which, however, did not show any clinical differences. The lack of IgM antibodies in the CSF of many patients diminished the value of CSF in the laboratory diagnosis of mumps meningitis compared to use of serum specimens. Intrathecal synthesis of mumps IgG antibodies was demonstrated in 83% of the patients, and of IgM antibodies in at least 67% of those patients with detectable IgM antibodies in CSF. The ratio between mumps IgG and IgM antibodies was higher in CSF than in serum, suggesting that the synthesis of IgG antibodies in central nervous system was more efficient than that of IgM antibodies.<\/jats:p>","DOI":"10.1002\/jmv.1890080406","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T03:20:28Z","timestamp":1172805628000},"page":"257-265","source":"Crossref","is-referenced-by-count":54,"title":["Local production of mumps IgG and IgM antibodies in the cerebrospinal fluid of meningitis patients"],"prefix":"10.1002","volume":"8","author":[{"given":"Pentti","family":"Ukkonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marja\u2010Lisa","family":"Granstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorma","family":"R\u00e4s\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eeva\u2010Marjatta","family":"Salonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Penttinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1943.tb09179.x"},{"key":"e_1_2_1_2_1","first-page":"17","article-title":"Meningo\u2010encephalitis in mumps","volume":"111","author":"Finkelstein H","year":"1938","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1978.tb02843.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1128\/iai.21.3.852-861.1978","article-title":"Cerebrospinal fluid and serum immunoglobulins and antibody titers in mumps meningitis and aseptic meningitis of other etiology","volume":"21","author":"Fryd\u00e9n A","year":"1978","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/inf.1978.10.issue-1.13"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1128\/jcm.12.6.764-767.1980","article-title":"Varicella\u2010zoster\u2010associated encephalitis: Detection of specific antibody in cerebrospinal fluid","volume":"12","author":"Gershon A","year":"1980","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890040310"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91132-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-140-36696"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1001\/jama.1978.03290040034018","article-title":"Simultaneous serum and CSF antibodies in herpes simplex virus encephalitis","volume":"240","author":"Levine DP","year":"1978","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_1_11_1","first-page":"177","article-title":"Characteristics of the immune response within the CNS in neurological disorders","volume":"57","author":"Link H","year":"1978","journal-title":"Acta Neurologica Scandinavica"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1971.00490040052007"},{"key":"e_1_2_1_13_1","first-page":"106","article-title":"The CSF IgG\u2010index for evaluation of lgG synthesis within the cenrral nervous system","volume":"54","author":"Link H","year":"1976","journal-title":"Acta Neurologica Scandinavica"},{"key":"e_1_2_1_14_1","first-page":"1060","article-title":"Local immunity in mumps meningitis","volume":"134","author":"Morishima T","year":"1980","journal-title":"American Journal of the Diseases of Children"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1978.tb00480.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1128\/iai.10.4.688-694.1974","article-title":"Comparison of antibodies against different viruses in cerebrospinal fluid and serum samples from patients with multiple sclerosis","volume":"10","author":"Norrby E","year":"1974","journal-title":"Infection and lmmunity"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1128\/iai.6.3.248-254.1972","article-title":"Identification of different measles virus\u2010specific antibodies in the serum and cerebrospinal fluid from patients with subacute sclerosing panencephalitis and multiple sclerosis","volume":"6","author":"Salmi A","year":"1972","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(81)90277-5"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1128\/jcm.11.4.319-323.1980","article-title":"Enzyme\u2010linked immunosorbent assay for mumps and parainfluenza type 1 immunoglobulin G and immunoglobulin M antibodies","volume":"11","author":"Ukkonen P","year":"1980","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890080207"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(81)90063-0"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890080406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890080406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T01:33:46Z","timestamp":1699839226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890080406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/jmv.1890080406"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890080406","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}