{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:40:04Z","timestamp":1791189604144,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"vor","delay-in-days":8740,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rift Valley fever virus (RFFV) has long been a major pathogen of domestic animals and humans in sub\u2010Saharan Africa. In the last 5 yr it has been recognized that this agent not only causes a self\u2010limited febrile illness in humans but may also lead to fatal hemorrhagic fever and encephalitis. In 1977 the disease invaded Egypt for the first time in recorded history, resulting in an extensive epizootic\/epidemic and threatening additional spread into the Middle East. Because of this unprecedented geographical extension and the florid human disease associated with it, we have studied the pathogenicity of an Egyptian isolate (Zagazig Hospital 501) for laboratory animals. During the course of these studies, inbred rat strains were found to have three distinct patterns of response. Wistar\u2010Furth and Brown Norway rats were exquisitely susceptible to the virus and died with extensive hepatic necrosis 3 to 5 days after inoculation of only 5 plaque\u2010forming units (pfu). Lewis, Buffalo, DA, and Fischer 344 rats resisted subcutaneous infection with 5 \u00d7 10<jats:sup>5<\/jats:sup> pfu. ACI and Maxx rats were moderately susceptible to the lethal effects of 5 \u00d7 10<jats:sup>3<\/jats:sup> to 5 \u00d7 10<jats:sup>5<\/jats:sup> pfu of the virus and died within 2 to 3 wk with encephalitis. These findings suggest that the genetic susceptibility of the host is responsible for the markedly different evolution of RVF in the rats. The clinical and virologic events following rat inoculation resembled the course of benign, encephalitic, or fulminant human disease. The inbred rat model may be useful in defining the critical determinants of severe human RVF and suggests that more attention should be directed to host genetic factors.<\/jats:p>","DOI":"10.1002\/jmv.1890100107","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T10:57:50Z","timestamp":1172833070000},"page":"45-54","source":"Crossref","is-referenced-by-count":48,"title":["Inbred rat strains mimic the disparate human response to rift valley fever virus infection"],"prefix":"10.1002","volume":"10","author":[{"given":"C. J.","family":"Peters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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I. Diagnosis of Rift Valley fever in man","volume":"57","author":"Imam IZE","year":"1979","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(79)90006-3"},{"key":"e_1_2_1_14_1","first-page":"8","article-title":"Rift Valley fever encephalitis: A description of a case","volume":"5","author":"Maar SA","year":"1979","journal-title":"Central African Journal of Medicine"},{"key":"e_1_2_1_15_1","first-page":"189","article-title":"Potential importation of dangerous exotic arbovirus diseases. A case report of Rift Valley fever with retinopathy","volume":"5","author":"Mahdy MS","year":"1979","journal-title":"Canadian Disease Weekly Report"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(79)90004-X"},{"key":"e_1_2_1_17_1","first-page":"267","article-title":"Emerging concepts on Rift valley fever","volume":"11","author":"Meegan JM","year":"1981","journal-title":"Perspectives in Virology"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/121.1.25"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000148858"},{"key":"e_1_2_1_20_1","first-page":"21","article-title":"Pathogenesis of Rift Valley fever","volume":"3","author":"Peters CJ","year":"1981","journal-title":"Contributions to Epidemiology and Biostatistics"},{"key":"e_1_2_1_21_1","first-page":"403","volume-title":"CRC Handbook Series in Zoonoses, Section B: Viral Zoonoses","author":"Peters CJ","year":"1981"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(80)90175-0"},{"key":"e_1_2_1_23_1","first-page":"926","article-title":"Macular changes in Rift Valley fever","volume":"25","author":"Schrire L","year":"1951","journal-title":"South African Medical Journal"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91395-1"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.64.5.366"},{"key":"e_1_2_1_26_1","first-page":"1","article-title":"Fatal Rift Valley fever of man in Rhodesia","volume":"25","author":"Swanepoel R","year":"1979","journal-title":"Central African Journal of Medicine"},{"key":"e_1_2_1_27_1","first-page":"867","article-title":"Rift Valley fever affecting humans in South Africa: A clinicopathological study","volume":"51","author":"Van Velden DJJ","year":"1977","journal-title":"South African Medical Journal"},{"key":"e_1_2_1_28_1","first-page":"293","article-title":"Rift Valley fever surveillance","volume":"54","author":"World Health Organization","year":"1979","journal-title":"Weekly Epidemiological Record"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890100107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890100107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:46:34Z","timestamp":1699836394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890100107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,1]]}},"alternative-id":["10.1002\/jmv.1890100107"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890100107","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,1]]}}}