{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:41:18Z","timestamp":1761662478466},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"vor","delay-in-days":8740,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Specific IgM class antibody production was studied in different groups of patients with characterized cytomegalovirus (CMV) infections using a radioimmunoassay (RIA). In pregnant women, IgM antibodies were detected only following primary infection and generally persisted less than 4 months. The demonstration of CMV\u2010specific IgM during pregnancy is therefore diagnostic of recent primary CMV infection.<\/jats:p><jats:p>In patients with symptomatic CMV infections, the appearance of IgM antibody was shown to be closely related to the onset of symptoms and coincided with production of complement fixing (CF) antibody. IgM antibodies were at maximum levels 3\u20134 weeks after presentation but generally declined to low or undetectable levels by 3\u20134 months. The significance of the results of testing for CMV\u2010specific IgM in relation to clinical and other serological findings in these patients is discussed.<\/jats:p><jats:p>IgM antibody production was also demonstrated in renal transplant patients with primary infections and in 6 of 21 recipients with secondary infections. In both groups the antibodies became detectable 3\u20136 weeks after transplantation but the titres were much higher following primary infection. IgM antibodies persisted throughout follow\u2010up periods of up to 2 years after transplantation in some cases.<\/jats:p>","DOI":"10.1002\/jmv.1890100306","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T11:06:14Z","timestamp":1172833574000},"page":"203-212","source":"Crossref","is-referenced-by-count":49,"title":["Specific IgM class antibody production following infection with cytomegalovirus"],"prefix":"10.1002","volume":"10","author":[{"given":"Hillar O.","family":"Kangro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond B.","family":"Heath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/143.6.821"},{"key":"e_1_2_1_3_1","first-page":"759","article-title":"Clinical manifestations of renal allograft derived primary cytomegalovirus infection","volume":"131","author":"Betts RF","year":"1977","journal-title":"American Journal of Diseases in Childhood"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400025730"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1981.tb01212.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.31.9.827"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1980.tb04546.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/145.2.647"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01314475"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197511272932201"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1128\/iai.15.3.883-889.1977","article-title":"Solid\u2010phase radioimmunoassay of human immunoglobulin M and immunoglobulin G antibodies against herpes simplex virus type 1 capsid, envelope and excreted antigens","volume":"15","author":"Kalimo KOK","year":"1977","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_12_1","first-page":"512","article-title":"Evaluation of a radioimmunoassay for IgM\u2010class antibodies against cytomegalovirus","volume":"61","author":"Kangro HO","year":"1980","journal-title":"British Journal of Experimental Pathology"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/2.3.449"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196905222802103"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400021926"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/143.4.618"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/142.1.9"},{"key":"e_1_2_1_18_1","first-page":"131","article-title":"Determination of different cytomegalovirus immunoglobulins (IgG, IgM, IgA) by immunofluorescence","volume":"37","author":"Schmitz H","year":"1972","journal-title":"Archives of Virology"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01314662"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890080203"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197107222850406"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890100306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890100306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:46:23Z","timestamp":1699836383000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890100306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1982,1]]}},"alternative-id":["10.1002\/jmv.1890100306"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890100306","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,1]]}}}