{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:55:55Z","timestamp":1759146955000},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":7645,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty marmosets, male Callithrix jacchus, were used during this study. Fifteen of the marmosets were inoculated with 5,000 TCID<jats:sub>50<\/jats:sub> of the attenuated XJCl3 strain of Junin virus by intramuscular route and five were left as uninoculated controls. Animals were observed for a 420\u2010day period. In order to carry out virologic, hematologic, serologic, and histologic studies the animals were bled and\/or killed at different days post infection(pi).<\/jats:p><jats:p>Results obtained showed that the attenuated strain produced an infection with no mortality or signs of illness. There was only a slight loss of weight at 18\u201340 days pi, which was soon recovered. Viremia was present from day 6 to 22, titers peaking at 4.0 log. Viral spread was limited to the lungs, spleen, lymph nodes, and bone marrow in the animal killed on day 14. No virus was found in the organs of the animal killed on day 23, and neither hematologic alterations nor pathologic lesions were seen in these monkeys except for ganglionar hypertrophy with immunoblast proliferation. Antigen was detected by immunofluorescence (IF) in lymph nodes, spleen, adrenals, lungs and brain.<\/jats:p><jats:p>Neutralizing antibodies were detected from the third week onward. Protection conferred by the XJC13 strain proved effective when XJCU\u2013inoculated monkeys were challenged with 1,000 TCID<jats:sub>50<\/jats:sub> of the pathogenic XJ strain at days 60 or 380 pi, while normal controls died.<\/jats:p><jats:p>When viral persistence was searched for on days 370, 390, and 420 pi, no infectious virus was detected, but viral antigen was seen in certain organs, which, however, lacked tissue damage.<\/jats:p><jats:p>Bearing in mind the main features differentiating the previously tested pathogenic and the attenuated strains, C jacchus may prove a useful model for testing the pathogenicity and efficacy of attenuated vaccines against Argentine hemorrhagic fever (AHF).<\/jats:p>","DOI":"10.1002\/jmv.1890150112","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:01:41Z","timestamp":1172836901000},"page":"93-100","source":"Crossref","is-referenced-by-count":13,"title":["Attenuated Junin virus infection in callithrix jacchus"],"prefix":"10.1002","volume":"15","author":[{"given":"Dra. M. M.","family":"Avila","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Frigerio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. L.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rondinone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Samoilovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P.","family":"Laguens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. B.","family":"de Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Weissenbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"597","article-title":"Infecci\u00f3n del cobayo con la cepa atenuada del virus Junin XJCL3. Medicina (Bs","volume":"39","author":"Avila MM","year":"1979","journal-title":"Aires)"},{"key":"e_1_2_1_3_1","first-page":"255","article-title":"Rescue of Jun\u00edn virus from adult mice by cocultivation procedures","volume":"2","author":"Berr\u00eda MI","year":"1983","journal-title":"Comunicaciones Biologicas"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000149517"},{"key":"e_1_2_1_5_1","first-page":"734","article-title":"El Cebus sp como modelo experimental para la Fiebre Hemorrigica Argentina. Medicina (Bs","volume":"40","author":"Carballal G","year":"1980","journal-title":"Aires)"},{"key":"e_1_2_1_6_1","first-page":"519","article-title":"Infecci\u00f3n de primates del Nuevo Mundo con virus Junin. III Saimiri sciurcus","volume":"42","author":"Frigerio MJ","year":"1982","journal-title":"Medicina (Bs. Aires)"},{"key":"e_1_2_1_7_1","first-page":"270","article-title":"Junin virus infection of Callithrix jacchus: Hematological findings","volume":"26","author":"Frigerio MJ","year":"1982","journal-title":"Acta Virol\u00f3gica"},{"key":"e_1_2_1_8_1","first-page":"1","article-title":"Inmunizaci\u00f3n contra la FHA con una cepa atcnuada dcl virus Junin. I Estudio de una cepa modificada del virus Junin. Inmunizaci\u00f3n de cobayos","volume":"29","author":"Guerrero de LB","year":"1969","journal-title":"Medicina (Bs. Aires)"},{"key":"e_1_2_1_9_1","first-page":"271","article-title":"Infecci\u00f3n experimental del cobayo con virus Junin. 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