{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:16:44Z","timestamp":1780561004101,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":7402,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1985,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The antibody response against flaviviruses tick\u2010borne encephalitis (TBE), Kyasanur Forest disease (KFD), Murray Valley encephalitis (MVE), West Nile fever (WNF), Japanese B encephalitis (JE), dengue 2 (DEN\u20102), and yellow fever (YF) was studied in humans after administration of an inactivated TBE virus vaccine. Individuals were either prevaccinated with 17D yellow fever (experimental group) or without any previous exposure to flaviviruses (control group). The appearance of serum titres of homologous and heterologous haemagglutination inhibition (HI) antibodies, heterotypic DEN\u20102 neutralizing antibodies, and TBE enzyme\u2010linked immunosorbent assay (ELISA) antibodies were examined.<\/jats:p><jats:p>Individuals prevaccinated with the 17D yellow fever developed an antibody pattern that contrasted with that of the control group. This pattern was characterized as follows: (1) Predominantly anti\u2010TBE IgG antibodies appeared earlier and in higher titres than in the control group, (2) heterologous HI antibodies crossreacting with the WN flavivirus subgroup preceded the appearance of homologous HI antibodies, (3) a broad spectrum HI response was observed against all flaviviruses tested, and (4) low titre heterotypic DEN\u20102 neutralizing antibodies were formed in about half of the cases. These observations are discussed in the context of cross\u2010reactivity, cross\u2010protection and virus infection enhancement.<\/jats:p>","DOI":"10.1002\/jmv.1890170106","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:20:23Z","timestamp":1172838023000},"page":"35-45","source":"Crossref","is-referenced-by-count":27,"title":["Human antibody response to immunization with 17D yellow fever and inactivated TBE vaccine"],"prefix":"10.1002","volume":"17","author":[{"given":"M.","family":"Kayser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Paasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pilaski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Blenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Heeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1110820"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1128\/iai.36.3.1036-1041.1982","article-title":"Infection enhancement of Dengue type 2 virus in the U\u2010937 human monocyte cell line by antibodies to flavivirus cross\u2010reactive determinants","volume":"36","author":"Brandt WE","year":"1982","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_4_1","first-page":"297","article-title":"Benefit versus risk factors in immunization against yellow fever","volume":"43","author":"Bres P","year":"1979","journal-title":"Developments in biological Standardization"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1958.7.561"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1128\/br.28.4.397-399.1964","article-title":"Labeling techniques in the diagnosis of viral diseases","volume":"28","author":"Coons AH","year":"1964","journal-title":"Bacteriological Reviews"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-38-1-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-23-1-91"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.4269\/ajtmh.1982.31.548","article-title":"Identification of distinct antigenic determinants on Dengue\u20102 virus using monoclonal antibodies","volume":"31","author":"Gentry MK","year":"1982","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_1_10_1","first-page":"24","article-title":"Immunological enhancement of dengue virus replication","volume":"243","author":"Halstead SB","year":"1973","journal-title":"Nature New Biology"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/140.4.527"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1980.29.638"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1128\/iai.40.3.995-1003.1983","article-title":"Pathogenesis and immune response of vaccinated and unvaccinated rhesus monkeys to tick\u2010borne encephalitis virus","volume":"40","author":"Hambleton P","year":"1983","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.4269\/ajtmh.1966.15.601","article-title":"Immunological studies with group B arthropod\u2010borne viruses. 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