{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:18Z","timestamp":1761058638894},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":7372,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1985,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Under double\u2010blind conditions, groups of volunteers (68 in total) were allocated at random to take intranasal solutions of placebo or one of three doses of highly purified leucocyte interferon by intranasal spray twice a day for 28 days. The highest dose would have been expected to protect against experimental colds. Treatment was discontinued because of upper respiratory symptoms as often in each of the interferon groups as in the placebo group. However, it was possible to distinguish clinically between \u201ccolds\u201d on placebo and low\u2010dose interferon and \u201creactions to treatment\u201d on high\u2010dose interferon. The features of the reactions to treatment were a protracted build\u2010up of local symptoms and minor epistaxis. None of the volunteers on the high\u2010dose interferon were thought to have a definite cold, but viruses were isolated from four out of six volunteers on low\u2010dose interferon who had definite colds. Previous experiments had also shown this dose to be insufficient to protect against experimental rhinovirus challenge.<\/jats:p><jats:p>The dose of interferon that appeared to protect against virus infection caused significant unwanted effects. It is essential to find interferon preparations with less inflammatory activity before interferon can be considered for use as a long\u2010term prophylactic against the common cold.<\/jats:p>","DOI":"10.1002\/jmv.1890170202","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:19:47Z","timestamp":1172837987000},"page":"99-106","source":"Crossref","is-referenced-by-count":18,"title":["Tolerance of one\u2010month intranasal interferon"],"prefix":"10.1002","volume":"17","author":[{"given":"G. M.","family":"Scott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. K.","family":"Onwubalili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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