{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T10:54:42Z","timestamp":1759056882464},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":7341,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1985,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During an epidemic of Japanese encephalitis (JE) in northern Thailand, cerebrospinal fluid (CSF) leukocytes and blood leukocytes from 28 patients with suspected JE were tested for spontaneous in vitro synthesis of antibodies to JE virus (JEV). Sixteen patients were subsequently proven to be infected with JEV. Supernatant fluids of three\u2010day cultures of unstimulated peripheral blood mononuclear leukocytes or unstimulated unfractionated CSF leukocytes were tested for JEV IgM and IgG antibodies with isotype\u2010specific \u201cantibody capture\u201d radioimmunoassays. Blood\u2010derived leukocytes from all sixteen JEV\u2010infected patients and CSF\u2010derived leukocytes from four JEV\u2010infected patients synthesized JEV antibodies. Bloodderived and CSF\u2010derived leukocytes from all 12 patients with central nervous system infections caused by agents other than JEV uniformly failed to synthesize JEV antibodies. Virus\u2010specific antibody\u2010producing cells can be detected in the blood and CSF early in the clinical course of acute JE.<\/jats:p>","DOI":"10.1002\/jmv.1890170310","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:18:49Z","timestamp":1172837929000},"page":"283-292","source":"Crossref","is-referenced-by-count":20,"title":["Virus\u2010specific antibody\u2010producing cells in blood and cerebrospinal fluid in acute Japanese encephalitis"],"prefix":"10.1002","volume":"17","author":[{"given":"Donald S.","family":"Burke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananda","family":"Nisalak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanida","family":"Lorsomrudee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Ussery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanom","family":"Laorpongse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.15.3.353-361.1982"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1128\/jcm.16.6.1034-1042.1982","article-title":"Antibody capture immunoassay detection of Japanese encephalitis virus immunoglobulin M and G antibodies in cerebrospinal fluid","volume":"16","author":"Burke DS","year":"1982","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_4_1","unstructured":"BurkeDS NisalakA UsseryMA LaorakpongseT ClantavibulS(1985):Kinetics of Japanese encephalitis virus immunoglobulin M and G antibodies in human serum and cerebrospinal fluid. 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