{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T15:07:42Z","timestamp":1726758462940},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":7160,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A single multisite intradermal (ID) administration of the same dose used for regular intramuscular (IM) immunisation with vaccine against tick\u2010borne encephalitis virus (TBEV) resulted in seroconversion of all vaccinees within three weeks: with the regular IM schedule, two vaccinations were necessary for all vaccinees to seroconvert. After the first ID vaccination, antibodies of the IgM class against TBEV (anti\u2010TBEV\u2010IgM) were observed in all vaccinees; after the first IM vaccination, only three out of nine vaccinees showed an IgM response. The geometric mean titer (GMT) of anti\u2010TBEV\u2010IgM in seropositives was 5\u201320\u2010fold higher in the ID group and similar to that after natural infection. The GMT of antibodies of the IgG class against TBEV (anti\u2010TBEV\u2010IgG) was also higher in the ID group but with a less marked difference. Hemagglutination\u2010inhibiting (HI) antibodies appeared earlier and persisted longer after one or two ID injections; after a third vaccination, HI antibody levels were similar in both groups.<\/jats:p><jats:p>Side effects after ID vaccination were limited to local reactions. These results indicate that follow\u2010up injections may be omitted or at least reduced after ID administration of the vaccine dose usually used for IM vaccination schedules. However, additional studies in larger groups of vaccinees are necessary before ID vaccination can be recommended for general use.<\/jats:p>","DOI":"10.1002\/jmv.1890190109","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:25:36Z","timestamp":1172838336000},"page":"55-61","source":"Crossref","is-referenced-by-count":13,"title":["Different immune responses after intradermal and intramuscular administration of vaccine against tick\u2010borne encephalitis virus"],"prefix":"10.1002","volume":"19","author":[{"given":"Gert","family":"Zoulek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Roggendorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Deinhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kunz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400039656"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1958.7.561"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1128\/jcm.14.2.141-146.1981","article-title":"Comparison of two different enzymeimmunoassays for the detection of immunoglobulin M antibodies against tick\u2010borne encephalitis virus in serum and cerebrospinal fluid","volume":"14","author":"Heinz F","year":"1981","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1128\/iai.33.1.250-257.1981","article-title":"Antigenic and immunogenic properties of defined physical forms of tick\u2010borne encephalitis virus structural proteins","volume":"33","author":"Heinz F","year":"1981","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890060202"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90800-0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91402-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5921.727-a"},{"key":"e_1_2_1_10_1","first-page":"389","article-title":"A controlled field trial on the effectiveness of the intradermal and subcutaneous administration of cholera vaccines in the Philippines","volume":"49","author":"Philippines Cholera Committee","year":"1973","journal-title":"Bulletin of the WHO"},{"key":"e_1_2_1_11_1","first-page":"694","volume-title":"Viral Hepatitis and Liver Disease","author":"Redfield RR","year":"1984"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(71)90039-0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890070105"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5807.197"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890140105"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890190109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890190109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T13:41:25Z","timestamp":1697895685000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890190109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,5]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,5]]}},"alternative-id":["10.1002\/jmv.1890190109"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890190109","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,5]]}}}