{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T12:42:47Z","timestamp":1749645767318},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":7160,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was carried out to determine the pathways along which two strains of Junin virus (JV), the pathogenic XJV and the attenuated XJC13V, reach the CNS following IP inoculation of 2\u2010day\u2010old rats. A sequential study of infectivity and antigen distribution in peritoneal macrophages, spleen, and brain was performed. Mortality was 85% with the former strain, but only 15% with the latter. At 4\u20137 days PI, XJV\u2010infected animals had viral antigen in 10% of peritoneal macrophages. Viremia and spleen virus lasted for 10\u201315 days. Low brain titers were detected at day 7, with a peak at day 15. Brain antigen correlated with virus titers. In contrast, XJC13V\u2010infected rats, macrophage antigen appeared later and to a lesser degree (1% of cells). Viremia and spleen virus were transient, while both the titer of brain virus and the viral antigen proved lower. Antibody titers were over twofold higher for XJ\u2010infected animals.<\/jats:p><jats:p>It is suggested that the different replication rate at the inoculation site could account for the greater ability of the XJV strain to reach the CNS. A greater antigen mass and\/or more numerous antigenic determinants presented by the macrophage could explain the higher antibody titers found in XJ\u2010infected rats, which were unable, however, to prevent viral spread.<\/jats:p>","DOI":"10.1002\/jmv.1890190111","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:25:36Z","timestamp":1172838336000},"page":"71-77","source":"Crossref","is-referenced-by-count":2,"title":["Junin virus access to CNS by extraneural rat inoculation"],"prefix":"10.1002","volume":"19","author":[{"given":"G. D.","family":"Lerman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Blejer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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