{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:59:27Z","timestamp":1761512367391},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":7134,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although indirect immunofluorescent antibody tests (IFAT) have been developed for several arenaviruses, none has been applied to the rhesus monkey model for Bolivian hemorrhagic fever (caused by the arenavirus Machupo). We infected eight rhesus monkeys with Machupo virus and bled them weekly for determination of viremia and for serum antibody detection by IFAT and serum neutralization (SN) testing. Viremia peaked day 14 post\u2010inoculation (PI), when two of eight animals had low IFAT titers. At day 21 PI, the six surviving monkeys had elevated IFAT titers and diminished viremias. SN titers were not observed until 28 days PI, when three of four survivors had low titers. Results of the IFAT were available more rapidly than the SN, and detected increased serum antibody titers earlier than the SN. Acetone fixation did not completely inactivate BHF antigen spot slides.<\/jats:p>","DOI":"10.1002\/jmv.1890190212","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:33:00Z","timestamp":1172838780000},"page":"187-192","source":"Crossref","is-referenced-by-count":6,"title":["Indirect immunofluorescence, serum neutralization, and viremia responses of rhesus monkeys (<i>Macaca mulatta<\/i>) to Machupo virus"],"prefix":"10.1002","volume":"19","author":[{"given":"Eric.","family":"Gonder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Eddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197808032990502"},{"key":"e_1_2_1_3_1","first-page":"517","article-title":"Pathogenesis of Machupo virus infection in primates","volume":"52","author":"Eddy GA","year":"1975","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_1_4_1","first-page":"884","volume-title":"Manual of Clinical Microbiology","author":"Jahrling PB","year":"1980"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-118-29772"},{"key":"e_1_2_1_6_1","first-page":"105","article-title":"Hemorrhagic fevers of Southeast Asia and South America: A comparative appraisal","volume":"9","author":"Johnson KM","year":"1967","journal-title":"Progress in Medical Virology"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/133.1.57"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1128\/am.26.3.239-243.1973","article-title":"Biological containment facility for studying infectious disease","volume":"26","author":"Kuehne RW","year":"1973","journal-title":"Applied Microbiology"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1128\/jcm.2.3.193-197.1975","article-title":"Comparison of three tests for the serological diagnosis of lymphocytic choriomeningitis virus infection","volume":"2","author":"Lewis VJ","year":"1975","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-142-37060"},{"key":"e_1_2_1_11_1","first-page":"513","volume-title":"Textbook of Human Virology","author":"Peters CJ","year":"1984"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(82)90018-0"},{"key":"e_1_2_1_13_1","first-page":"169","volume-title":"Ribavirin: A Broad Spectrum Antiviral Agent","author":"Stephen EL","year":"1980"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91831-7"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-130-33711"},{"key":"e_1_2_1_16_1","first-page":"429","article-title":"Indirect immunofluorescence for the diagnosis of Lassa fever infection","volume":"52","author":"Wulff H","year":"1975","journal-title":"Bulletin of World Health Organization"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000148956"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890190212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890190212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T18:26:08Z","timestamp":1697999168000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890190212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,6]]}},"alternative-id":["10.1002\/jmv.1890190212"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890190212","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,6]]}}}