{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:47:06Z","timestamp":1777502826212,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":7103,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although case reports of herpes simplex virus (HSV) causing acute hepatitis in otherwise healthy adults have appeared recently in the literature, a prospective study of the incidence of HSV\u2010hepatitis in the general population hitherto has not been reported. In the present study, serum samples from 124 young adults attending a sexually transmitted disease clinic with either genital herpes infections (n = 86) or non\u2010herpes sexually transmitted diseases (n = 38) (controls) were analyzed for liver enzyme abnormalities (including aspartate aminotransferase [AST] and alanine aminotransferase [ALT]). Twelve of eighty\u2010six (14%) herpes\u2010infected patients had mildly abnormal liver enzyme tests (\u2264 twice the upper limit of normal) as opposed to only 1 of 38 controls (2.6%), (P &lt; .05). All individuals in the herpes\u2010hepatitis group were anicteric, and only two complained of constitutional symptoms (malaise and fatigue). Liver enzyme tests were repeated in nine herpes\u2010hepatitis patients 1 week after their genital lesions had resolved, and in six of nine patients the results had returned to within normal limits. Four patients subsequently returned at the onset of a recurrence of their genital herpes. In all four, serum ALT levels were elevated from the previous occasion, and in three of the four levels just exceeded the upper limit of normal. One patient was followed through three recurrences of his genital herpes. In that individual, the extent of liver enzyme abnormalities appeared to correlate with the presence or absence of his genital lesions. The results of this study indicate that individuals with genital herpes infections more commonly have elevated liver enzyme levels than individuals with non\u2010herpes sexually transmitted disease. The limited extent of the enzyme elevations, however, suggests that genital herpes is rarely associated with significant liver disease in healthy young adults.<\/jats:p>","DOI":"10.1002\/jmv.1890190309","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:31:12Z","timestamp":1172838672000},"page":"269-275","source":"Crossref","is-referenced-by-count":23,"title":["Genital herpes and hepatitis in healthy young adults"],"prefix":"10.1002","volume":"19","author":[{"given":"G.Y.","family":"Minuk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.E.","family":"Nicolle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80160-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5158.993"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1959.02070020168005"},{"key":"e_1_2_1_5_1","first-page":"146","volume-title":"Infectious Mononucleosis","author":"Carter RL","year":"1969"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0016-5085(79)80229-2","article-title":"Lethal herpes simplex virus type 1 hepatitis in a normal adult","volume":"76","author":"Connor RW","year":"1979","journal-title":"Gastroenterology"},{"key":"e_1_2_1_7_1","first-page":"370","article-title":"Stability of aspartate aminotransferase and alanine aminotransferase activities","volume":"102","author":"Cuccherini B","year":"1983","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1969.tb01455.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0016-5085(83)90336-0","article-title":"Non\u2010A, non\u2010B hepatitis. 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Recognition, epidemiology, and clinical features","volume":"85","author":"Dienstag JL","year":"1983","journal-title":"Gastroenterology"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80464-7"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.22.1.60"},{"key":"e_1_2_1_12_1","first-page":"329","article-title":"Fulminant hepatitis due to herpes hominis in an adult human","volume":"57","author":"Francis TJ","year":"1972","journal-title":"American Journal of Gastroenterology"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.209.8.1219"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.208.5.859"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90643-3"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103055"},{"key":"e_1_2_1_17_1","first-page":"647","article-title":"Fatal disseminated primary herpes infection in children: Epidemiology based on 93 non\u2010neonatal cases","volume":"41","author":"Kipps A","year":"1967","journal-title":"South African Medical Journal"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840010516"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(74)80025-0"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840040309"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90487-2"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196308292690906"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(59)90175-5"},{"key":"e_1_2_1_24_1","first-page":"421","article-title":"Herpes simplex virus as the cause of fulminating visceral disease and hepatitis in infancy","volume":"83","author":"Zuelzer WW","year":"1952","journal-title":"American Journal of Digestive Diseases"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890190309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890190309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T02:04:57Z","timestamp":1697853897000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890190309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,7]]}},"alternative-id":["10.1002\/jmv.1890190309"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890190309","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,7]]}}}