{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:09:54Z","timestamp":1773796194250,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":7041,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1986,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to determine whether Jun\u00edn virus persistence in CNS of rats was capable of inducing late neurologic disease. Following intracerebral inoculation of newborn animals with XJ strain, three distinct stages could be discerned: an early phase of acute disease, up to 30 days pi, with 5% mortality; an intermediate one, extending to 280 days pi, without clinical signs but with evident viral persistence; and a final period of chronic illness, featuring clinical neurologic syndrome, severe perivascular inflammatory reaction, PAP\u2010labeled viral antigen in a few cerebral and cerebellar neurons, and virus recovery only by coculture. Late neurologic disease seems associated to the lack of effective clearance of brain virus, leading to viral persistence and long lasting immunologic stimulation. The importance of animal models for pathogenic studies on CNS persistent viral infections leading to late neurologic disease is stressed.<\/jats:p>","DOI":"10.1002\/jmv.1890200108","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:57:09Z","timestamp":1172840229000},"page":"57-65","source":"Crossref","is-referenced-by-count":12,"title":["Chronic Neurologic Disease in Jun\u00edn Virus\u2010Infected Rats"],"prefix":"10.1002","volume":"20","author":[{"given":"Mercedes C.","family":"Weissenbacher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo F.","family":"Lascano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda M.","family":"Avila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda I.","family":"Berr\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"235","article-title":"Immunoperoxidase detection of yellow fever virus after natural and experimental infections","volume":"35","author":"de la Monte SM","year":"1983","journal-title":"Tropical and Geographical Medicine"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/4.5.999"},{"key":"e_1_2_1_4_1","first-page":"459","article-title":"Measles antigen distribution in brain of chronically infected hamsters","volume":"5","author":"Johnson KP","year":"1977","journal-title":"Laboratory Investigation"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/103.3.447"},{"key":"e_1_2_1_6_1","volume-title":"Viral Infections of the Nervous System","author":"Johnson RT","year":"1982"},{"key":"e_1_2_1_7_1","first-page":"391","article-title":"Infecci\u00f3n cr\u00f3nica con virus Jun\u00edn en la rata: Estudios patol\u00f3gicos y vir\u00f3logicos","volume":"43","author":"Laguens RP","year":"1983","journal-title":"Medicina (Buenos Aires)"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01320797"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00703202"},{"key":"e_1_2_1_10_1","volume-title":"Lymphocytic Choriomeningitis Virus and Other Arenaviruses","author":"Lehmann\u2010Grube F","year":"1972"},{"key":"e_1_2_1_11_1","volume-title":"Immunology of the Nervous System","author":"Leibowitz S","year":"1982"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92335-3"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01309260"},{"key":"e_1_2_1_14_1","first-page":"57","article-title":"Location and distribution of virus antigen in the central nervous system of mice persistently infected with Theiler's virus","volume":"64","author":"Sathi P","year":"1983","journal-title":"British Journal of Experimental Pathology"},{"key":"e_1_2_1_15_1","first-page":"104","volume-title":"Immunocytochemistry","author":"Sternberger LA","year":"1979"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/B978-0-407-00253-1.50024-4","volume-title":"Textbook of Medical Virology","author":"Strannegard O","year":"1983"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890200108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890200108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T22:35:46Z","timestamp":1695767746000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890200108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,9]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,9]]}},"alternative-id":["10.1002\/jmv.1890200108"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890200108","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,9]]}}}