{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T06:41:44Z","timestamp":1770014504193,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":6980,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1986,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to assess the effect of the antiviral Ribavirin on the course of Junin virus infection in Callithrix jacchus, seven inoculated monkeys were treated with 15 mg of the drug, twice a day, starting 6 days after infection when all animals were viremic. The three untreated controls showed typical signs of Junin virus infection at 14 days pi and their mean time of death was 18 days. In contrast, no signs of illness were detected in Ribavirin\u2010treated animals until 24 days pi, when marmosets showed signs of neurological involvement: 5 of these animals died (mean day of death: 36) but the two remaining treated monkeys improved and survived infection without sequelae. The comparison of survival rates (0% vs 28%) and the delay of the mean day of death observed indicates that the Ribavirin treatment used has therapeutic effect on Junin virus infection in vivo.<\/jats:p>","DOI":"10.1002\/jmv.1890200308","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:51:30Z","timestamp":1172839890000},"page":"261-267","source":"Crossref","is-referenced-by-count":36,"title":["Therapeutic Effect of the Antiviral Agent Ribavirin in Junin Virus Infection of Primates"],"prefix":"10.1002","volume":"20","author":[{"given":"Mercedes C.","family":"Weissenbacher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Calello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S.","family":"Merani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph B.","family":"McCormick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1983.32.417"},{"key":"e_1_2_1_3_1","volume-title":"Clinical Applications of Ribavirin","author":"Huggins JW","year":"1984"},{"key":"e_1_2_1_4_1","first-page":"567","article-title":"Clinical and epidemiological patterns of Argentine Hemorrhagic Fever","volume":"52","author":"Maiztegui JI","year":"1975","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92335-3"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198601023140104"},{"key":"e_1_2_1_7_1","volume-title":"Antiviral Agents and Viral Diseases of Man","author":"Muller EGW","year":"1979"},{"key":"e_1_2_1_8_1","first-page":"2300","article-title":"La etiologia de la fiebre hemorragica epidemica de la pcia","volume":"30","author":"Parodi AS","year":"1958","journal-title":"De Buenos Aires. Dia medico."},{"key":"e_1_2_1_9_1","volume-title":"Ribavirin: A Broad Spectrum Antiviral Agent","author":"Sidwell RW","year":"1980"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.177.4050.705"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000149059"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890200308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890200308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T19:30:21Z","timestamp":1697830221000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890200308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,11]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,11]]}},"alternative-id":["10.1002\/jmv.1890200308"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890200308","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,11]]}}}