{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T07:41:17Z","timestamp":1770018077445,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":6915,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Argentine hemorrhagic fever (Jun\u00edn virus) is a human viral disease for which immune therapy proves effective, though a late neurologic syndrome is occasionally associated with the treatment. We attempted to determine in the infected marmoset Cullithrix jacchus whether immune therapy leads to protection and\/or CNS damage.<\/jats:p><jats:p>Fifteen C <jats:italic>jacchus<\/jats:italic> were inoculated with 10<jats:sup>3<\/jats:sup> tissue culture infectious dose 50% (TCID<jats:sub>50<\/jats:sub>) of the XJ strain of Junin virus. On day 6 post infection (pi), 12 primates were treated with homologous immune serum. Animals were observed daily; and hematologic, serologic, virologic, and histologic studies were performed.<\/jats:p><jats:p>All primates, both treated and controls, presented leukopenia, thrombocytopenia, anemia, and weight loss from day 14 pi onward. The three control animals died on days 22, 25, and 32 pi. Among the 12 treated monkeys, 3 died on days 21, 22, and 29. Hematologic values returned to normal during the second month; initial weight was recovered by the fourth month. Three out of the nine survivors showed neurologic alterations of various degrees, with hind\u2010limb paralysis in the most severe case. Among treated monkeys, viremia and viral titers in the lungs, kidney, and lymph nodes were lower than in controls. Neutralizing antibodies were present in high titers in all treated marmosets, except in the one presenting paralysis in which values were minimal and viral persistence was detected in CNS.<\/jats:p><jats:p>In conclusion, immune serum treatment of Junin virus\u2010infected marmosets was found to reduce mortality from 100% to 25%. Viremia and viral titers in organs were lowered, and late neurologic signs appeared in 30% of treated survivors.<\/jats:p>","DOI":"10.1002\/jmv.1890210109","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T13:09:15Z","timestamp":1172840955000},"page":"67-74","source":"Crossref","is-referenced-by-count":33,"title":["Protection of jun\u00edn virus\u2010infected marmosets by passive administration of immune serum: Association with late neurologic signs"],"prefix":"10.1002","volume":"21","author":[{"given":"Mar\u00eda M.","family":"Avila","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio R.","family":"Sarnoilovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rub\u00e9n P.","family":"Laguens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S.","family":"Merani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes C.","family":"Weissenbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"333","article-title":"Efecto del tratamiento con inmunosuero en ratas infectadas con virus Jun\u00edn. Medicina (Bs","volume":"42","author":"Avila MM","year":"1982","journal-title":"Aires)"},{"key":"e_1_2_1_3_1","first-page":"68","article-title":"Acci\u00f3n de los inmunosueros sobre la respuesta inmune en la fiebre hemorr\u00e1gica experimental. Medicina (Bs","volume":"33","author":"Carballal G","year":"1973","journal-title":"Aires)"},{"key":"e_1_2_1_4_1","first-page":"723","article-title":"Protection of monkeys against Machupo virus by the passive administration of Bolivian haemorrhagic fever immunoglobulin (human origin)","volume":"52","author":"Eddy GA","year":"1975","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_1_5_1","first-page":"270","article-title":"Jun\u00edn virus infection of Callithrix jacchus, hematological findings","volume":"26","author":"Frigerio MJ","year":"1982","journal-title":"Acta Virol\u00f3gica"},{"key":"e_1_2_1_6_1","first-page":"287","article-title":"Acci\u00f3n de los inmunosueros homol\u00f3gos en la fiebre hemorr\u00e1gica experimental. 1. Efecto sobre la concentraci\u00f3n de catepsinas en suero. Medicina (Bs","volume":"32","author":"Giovanniello OA","year":"1972","journal-title":"Aires)"},{"key":"e_1_2_1_7_1","first-page":"621","article-title":"Modificaci\u00f3n del curso de la infecci\u00f3n del cobayo con virus Jun\u00edn por administraci\u00f3n de inmunosuero. Medicina (Bs","volume":"45","author":"Laguens RM","year":"1985","journal-title":"Aires)"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92335-3"},{"key":"e_1_2_1_9_1","first-page":"237","article-title":"Passive immunity against Jun\u00edn virus in mice","volume":"19","author":"Nejamkis MR","year":"1975","journal-title":"Acta Virol\u00f3gica"},{"key":"e_1_2_1_10_1","first-page":"493","article-title":"A simple method of estimating fifty per cent end points","volume":"27","author":"Reed L","year":"1938","journal-title":"American Journal of Hygiene"},{"key":"e_1_2_1_11_1","first-page":"53","article-title":"Acci\u00f3n de los inmunosueros en la fiebre hemorr\u00e1gica experimental","volume":"28","author":"Weissenbacher MC","year":"1968","journal-title":"Medicina (Bs. Aires)"},{"key":"e_1_2_1_12_1","first-page":"21","article-title":"Infecci\u00f3n de primates del Nuevo Mundo con virus Jun\u00edn. II Callithrix jacchus. Medicina (Bs","volume":"40","author":"Weissenbacher MC","year":"1980","journal-title":"Aires)"},{"key":"e_1_2_1_13_1","first-page":"119","article-title":"Fiebre hemorr\u00e1gica argentina","volume":"2","author":"Weissenbacher MC","year":"1983","journal-title":"Adelantos en Microbiolog\u00eda de la Enfermedades Infecciosas"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890210109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890210109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T20:03:22Z","timestamp":1698005002000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890210109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/jmv.1890210109"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890210109","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}