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Twenty\u2010eight had hepatitis B virus DNA\u2010polymerase activity and\/or hepatitis B virus DNA in serum at entry into the study. There were no significant adverse effects of therapy. At 12 months, seroconversion from HBeAg to anti\u2010HBe had occurred in four of 15 treated patients, one of whom had also developed anti\u2010HBs, compared with only one of 15 in the untreated group (95 % confidence limits 12 % and 51 %). Seroconversion from HBeAg to anti\u2010HBe was accompanied by return of serum liver function tests to normal and improved liver histology. The results of this study indicate that acyclovir is of no significant benefit in chronic HBeAg carriers with stable disease.<\/jats:p>","DOI":"10.1002\/jmv.1890210111","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T13:09:15Z","timestamp":1172840955000},"page":"81-87","source":"Crossref","is-referenced-by-count":48,"title":["Controlled clinical trial of acyclovir in chronic hepatitis B virus infection"],"prefix":"10.1002","volume":"21","author":[{"given":"Graeme J. M.","family":"Alexander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Fagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Hegarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian L. W. 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