{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:13:52Z","timestamp":1762251232497},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":6764,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dengue 2 (DEN\u20102) strains isolated from children during the 1980 metropolitan Bangkok epidemic were shown to possess antigenic homogeneity when studied for determinants mediating antibody\u2010dependent infection enhancement using DEN\u20102 monnoclonal antibodies. All isolates possessed multiple enhancing determinants, but those associated with mild and severe dengue syndromes could not be distinguished. Either the basis of disease severity in dengue is more complex than the mere presence or absence of virus epitopes involved in enhanced infection or enhancing epitopes have differences not detected in this system with monoclonal antibodies raised to the same serotype.<\/jats:p>","DOI":"10.1002\/jmv.1890220207","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T13:30:41Z","timestamp":1172842241000},"page":"163-167","source":"Crossref","is-referenced-by-count":23,"title":["Study of the distribution of antibody\u2010 dependent enhancement determinants on dengue 2 isolates using dengue 2\u2010derived monoclonal antibodies"],"prefix":"10.1002","volume":"22","author":[{"given":"David M.","family":"Morens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda K.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott B.","family":"Halstead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1128\/iai.36.3.1036-1041.1982","article-title":"Infection enhancement of dengue type 2 virus in the U\u2010937 human monocyte line by antibodies to flavivirus cross\u2010reactive determinants","volume":"36","author":"Brandt WE","year":"1982","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.2307\/2528732"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.4269\/ajtmh.1982.31.548","article-title":"Identification of distinct antigenic determinants on dengue\u20102 virus using monoclonal antibodies","volume":"31","author":"Gentry MK","year":"1982","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.4049\/jimmunol.132.3.1529","article-title":"Heterogeneity of infection enhancement of dengue 2 strains by monoclonal antibodies","volume":"132","author":"Halstead SB","year":"1984","journal-title":"Journal of Immunology"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4269\/ajtmh.1985.34.162","article-title":"Epitopic analysis of antigenic determinants on the surface of dengue\u20102 virions using monoclonal antibodies","volume":"34","author":"Henchal EA","year":"1985","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1128\/jcm.22.2.250-254.1985","article-title":"Simplified plaque reduction neutralization assay for dengue viruses by semimicro methods in BHK\u201021 cells: Comparison of the BHK suspension test with standard plaque reduction neutralization","volume":"22","author":"Morens DM","year":"1985","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890220208"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890220207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890220207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T22:11:27Z","timestamp":1695766287000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890220207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,6]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,6]]}},"alternative-id":["10.1002\/jmv.1890220207"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890220207","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,6]]}}}