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DEN\u20102 strains associated with DHF typically had multiple determinants that were involved in antibody\u2010dependent enhancement of infection, whereas those associated with uncomplicated disease had few. These data provide further evidence that in epidemic areas where DHF is associated with prior circulation of low\u2010level monotypic antibody, severe dengue disease could represent antibody\u2010enhanced infection of human monocyted macrophages.<\/jats:p>","DOI":"10.1002\/jmv.1890220208","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T13:30:41Z","timestamp":1172842241000},"page":"169-174","source":"Crossref","is-referenced-by-count":22,"title":["Disease severity\u2010related antigenic differences in dengue 2 strains detected by dengue 4 monoclonal antibodies"],"prefix":"10.1002","volume":"22","author":[{"given":"David M.","family":"Morens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott B.","family":"Halstead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/2528732"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113235"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4269\/ajtmh.1983.32.157","article-title":"Comparison of P388DI mouse macrophage cell line and human monocytes for assay of dengue\u20102 infection\u2010enhancing antibodies","volume":"32","author":"Halstead SB","year":"1983","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.4049\/jimmunol.132.3.1529","article-title":"Heterogeneity of infection enhancement of dengue 2 strains by monoclonal antibodies","volume":"132","author":"Halstead SB","year":"1984","journal-title":"Journal of Immunology"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1128\/jcm.22.2.250-254.1985","article-title":"Simplified plaque reduction neutralization assay for dengue viruses by semi\u2010micro methods in BHK\u201021 cells: Comparison of the BHK suspension test with standard plaque reduction neutralization","volume":"22","author":"Morens DM","year":"1985","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1986.35.197"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-68-1-91"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890220207"},{"key":"e_1_2_1_10_1","volume-title":"Guide for Diagnosis. 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