{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:43:52Z","timestamp":1761155032430},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":6734,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1987,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role that polymorphonuclear leukocytes (PMN) may play in Argentine hemorrhagic fever (AHF), an endemo\u2010epidemic disease caused by Junin virus (JV), was investigated in experimentally infected guinea pigs depleted of PMN by means of specific antiserum. In leucopenic animals the evolution of the infection with a highly pathogenic strain of JV was more severe, with earlier mortality and higher virus yields in blood and viscera. The pathological study showed similar lesions in both the control and PMN\u2010depleted animals with the exception of the lung, which showed the pathological picture of the human \u201cpulmonary distress syndrome of the adult\u201d in nontreated guinea pigs and appeared histologically unaltered in the PMN\u2010depleted animals. On the basis of these results it is suggested that in AHF, PMN play a dual role. In the first stage of infection they display a defensive antiviral action, but later on they participate in the pathogenesis of tissue damage.<\/jats:p>","DOI":"10.1002\/jmv.1890220313","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T13:30:19Z","timestamp":1172842219000},"page":"289-297","source":"Crossref","is-referenced-by-count":10,"title":["Effect of polymorphonuclear depletion on experimental argentine hemorrhagic fever in guinea pigs"],"prefix":"10.1002","volume":"22","author":[{"given":"Pedro Horacio","family":"Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Ponzinibbio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben Pedro","family":"Laguens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"186","article-title":"Estudios Immunol\u00f3gicos en la Fiebre Hemorr\u00e1gia Argentina","volume":"32","author":"Arana RM","year":"1977","journal-title":"Medicina (Bs. 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