{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T07:31:57Z","timestamp":1698132717399},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":6703,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1987,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Six hundred forty\u2010three children, negative for markers of hepatitis B virus (HBV) infections. were given three \u00d7 2\u2010\u03bcg doses of Merck, Sharp and Dohme (MSD) plasma derived hepatitis B vaccine (H\u2010B\u2010Vax) at monthly intervals. Twelve months after the first dose of vaccine, antibody to hepatitis B surface antigen (anti\u2010HBs) was detected in 89% of children by radioimmunoassay (RIA) and in 83% by enzyme immunoassay (EIA). Seroconversion rates and anti\u2010HBs titres were significantly greater in 1\u20104\u2010year\u2010olds than in older children (p &lt; 0.01). Eighteen children with no anti\u2010HBs or other markers of HBV at this time were given 10 pg of vaccine and tested one month later. Seventeen developed anti\u2010HBs. 12 at levels consistent with an anamnestic response.<\/jats:p><jats:p>Forty\u2010nine HBV\u2010marker\u2010negative children seroconverted for antibody to hepatitis B core antigen (anti\u2010HBc) in the 8\u2010month period before or the 12\u2013month period following vaccination. Forty\u2010six of these children were positive for anti\u2010HBs, and one has been confirmed as a chronic carrier of hepatitis B surface antigen (HBsAg). Three cases of clinical hepatitis B in children have been seen in the community since the vaccination programme began. Two of these were amongst the estimated 5% of children who were not vaccinated. The third was in a vaccine and occurred 4\u00bd months after the last dose of vaccine.<\/jats:p><jats:p>These findings suggest that under the conditions of this programme, three intramuscular doses of 2 \u03bcg H\u2010B\u2010Vax given at monthly intervals provided effective protection for most children for at least 24 months, especially younger children who are at greatest risk of becoming HBsAg carriers.<\/jats:p>","DOI":"10.1002\/jmv.1890220412","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T13:28:31Z","timestamp":1172842111000},"page":"387-392","source":"Crossref","is-referenced-by-count":3,"title":["Low\u2010dose vaccination against hepatitis B in children: One\u2010year follow\u2010up"],"prefix":"10.1002","volume":"22","author":[{"given":"Alexander","family":"Milne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Dimitrakakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Allwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Goldwater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saul","family":"Krugman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92195-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198607243150401"},{"key":"e_1_2_1_4_1","first-page":"887","article-title":"Hepatitis infection in New Zealand children","volume":"97","author":"Hermon YE","year":"1984","journal-title":"New Zealand Medical Journal"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92926-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890170306"},{"key":"e_1_2_1_7_1","first-page":"529","article-title":"Prevalence of hepatitis B infections in a multi\u2010racial New Zealand community","volume":"98","author":"Milne A","year":"1985","journal-title":"New Zealand Medical Journal"},{"key":"e_1_2_1_8_1","first-page":"73","article-title":"Hepatitis B virus infections","volume":"98","author":"Milne A","year":"1985","journal-title":"New Zealand Medical Journal"},{"key":"e_1_2_1_9_1","first-page":"47","article-title":"Low dose hepatitis B vaccination in children","volume":"99","author":"Milne A","year":"1986","journal-title":"New Zealand Medical Journal"},{"key":"e_1_2_1_10_1","volume-title":"Pathology Laboratory","author":"Records of clinical infections with hepatitis B","year":"1976"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890220412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890220412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T14:36:54Z","timestamp":1697899014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890220412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,8]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,8]]}},"alternative-id":["10.1002\/jmv.1890220412"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890220412","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,8]]}}}