{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:37:00Z","timestamp":1760204220554},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":6672,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1987,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The \u201cin vivo\u201d interferon (IFN) induction capacity of two Jun\u00edn virus strains\u2014the attenuated XJCI, and the intermediate virulent MC<jats:sub>2<\/jats:sub>\u2014was studied in the guinea pig experimental model.<\/jats:p><jats:p>Three different doses of XJCI<jats:sub>3<\/jats:sub> strain\u20142,000, 10,000, and 50,000 TCID<jats:sub>50<\/jats:sub>\u2014and a single dose of 10,000 TCID<jats:sub>50<\/jats:sub> of MC<jats:sub>2<\/jats:sub> were assayed.<\/jats:p><jats:p>Animals were bled from day 0 to day 14 postinjection (pi) XJCl<jats:sub>3<\/jats:sub> groups showed a constant serum IFN response. MC<jats:sub>2<\/jats:sub> infection showed that 16% of the animals failed to develop interferonemia. The IFN activity was alpha type in most cases. The IFN serum levels induced by the MC<jats:sub>2<\/jats:sub> strain were always lower than those attained after XJCl<jats:sub>3<\/jats:sub> infection. The response to the positive control assayed, Newcastle disease virus, was higher and earlier than that obtained for Jun\u00edn virus strains. The highest IFN individual value, which induced 160 guinea pig IFN U\/ml, was detected at day 2 following XJCl<jats:sub>3<\/jats:sub> infection, and corresponded to the highest XJCl<jats:sub>3<\/jats:sub> dose assayed. Average values ranged from 23 to 65 guinea pig IFN U\/ml, for XJCl<jats:sub>3<\/jats:sub> groups and 15 guinea pig IFN U\/ml for the MC<jats:sub>2<\/jats:sub> group, measured at the day of maximal response.<\/jats:p><jats:p>IFN presence was studied in homogenates from brain, spleen, and lymph nodes; it was detected in organs from guinea pigs infected with XJCI<jats:sub>3<\/jats:sub> but not in organs from MC<jats:sub>2<\/jats:sub> infected animals.<\/jats:p><jats:p>IFN levels in sera or in organs failed to correlate with the histological findings.<\/jats:p><jats:p>Demonstration of viral antigens in organs of infected animals, and seroconversion of Jun\u00edn virus (JV) confirmed the evolution of the disease. A significant weight loss was observed just after serum IFN disappearance. Infection with different viral doses produced different mortality rates, although no correlation could be established between death and previous IFN level.<\/jats:p><jats:p>We demonstrated low IFN levels in JV infection of the guniea pig, which were in direct relation to the viral dose employed. The MC<jats:sub>2<\/jats:sub> strain exhibited a lower capacity of IFN induction than XJCl<jats:sub>3<\/jats:sub>.<\/jats:p>","DOI":"10.1002\/jmv.1890230110","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T13:41:42Z","timestamp":1172842902000},"page":"83-91","source":"Crossref","is-referenced-by-count":12,"title":["Interferon response in the guinea pig infected with Jun\u00edn virus"],"prefix":"10.1002","volume":"23","author":[{"given":"Cristina B.","family":"Dejean","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethy L.","family":"Ayerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e9lica R.","family":"Teyssi\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"597","article-title":"Infecci\u00f3n del cobayo con la cepa atenuada del virus Junin XJC13","volume":"39","author":"Avila MM","year":"1979","journal-title":"Medicina (Buenos Aim)"},{"key":"e_1_2_1_3_1","first-page":"22","article-title":"Inducci\u00f3n de interferon \u201cin vitro\u201d por virus Jun\u00edn: Efecto del pretratamiento con el inhibidor","volume":"9","author":"Ayerra de Holstein BL","year":"1977","journal-title":"Revista de la Asociaci\u00f3n Argentina de Microbiolog\u00eda"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4049\/jimmunol.96.1.17","article-title":"Role of interferon during viremia. II. Protective action of circulating interferon","volume":"96","author":"Baron S","year":"1966","journal-title":"The Journal of Immunology"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01242631"},{"key":"e_1_2_1_6_1","first-page":"420","article-title":"Effect of interferon on cell mediated immunity","volume":"41","author":"De Maeyer E","year":"1981","journal-title":"Texas Reports on Biology and Medicine"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.144.5.1316"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-57-2-275"},{"key":"e_1_2_1_9_1","first-page":"135","article-title":"Induction of the interferon protein in vivo: Viral inducers","volume":"41","author":"Jameson P","year":"1981","journal-title":"Texas Reports"},{"key":"e_1_2_1_10_1","first-page":"411","article-title":"Effect of interferon on antibody formation","volume":"41","author":"Johnson HM","year":"1981","journal-title":"Texas Reports on Biology and Medicine."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1985.5.383"},{"key":"e_1_2_1_12_1","unstructured":"LuscriBJ(1976):Appendix A: Technical support for the bioassay of interferons. In Annual Progress Report Fiscal Year 1976. US Army Medical Research Institute of Infectious Diseases pp425\u2013429."},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.4269\/ajtmh.1984.33.1251","article-title":"The guinea pig model for Argentine Hemorrhagic Fever","volume":"33","author":"Oubi\u00f1a JR","year":"1984","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-64-8-1827"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.152.3.633"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(82)90524-4"},{"key":"e_1_2_1_17_1","first-page":"87","volume-title":"IFN 1983","author":"Scott GM","year":"1983"},{"issue":"3","key":"e_1_2_1_18_1","first-page":"53","article-title":"Interferon en la infecci\u00f3n \u201cin vitro\u201d con Virus Jun\u00edn","volume":"37","author":"Teyssi\u00e9 AR","year":"1977","journal-title":"Medicina (Buenos Aires)"},{"key":"e_1_2_1_19_1","first-page":"573","article-title":"Interferon en la infecci\u00f3n experimental con virus Jun\u00edn","volume":"41","author":"Teyssi\u00e9 AR","year":"1981","journal-title":"Medicina (Buenos Aires)"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890230110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890230110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T09:33:37Z","timestamp":1697967217000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890230110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,9]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,9]]}},"alternative-id":["10.1002\/jmv.1890230110"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890230110","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,9]]}}}