{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:40:40Z","timestamp":1744177240850},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":6611,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tacaribe virus is know to protect guinea pigs and primates against lethal challenge with Jun\u00edn virus. A long\u2010term study on the effect of Tacaribe virus infection in the guinea pig was carried out to determine the extent of cross\u2010protection and whether antigen and\/or viral persistence and tissue damage could be detected in immune animals. Viral titers, antigen expression in organs, and histologic lesions were sequentially searched for up to 540 days postinfection (pi). Neutralizing antibodies (Abs) and cross\u2010protection to Jun\u00edn virus were evaluated up to 660 days pi. Tacaribe virus titers and antigen peaked at 7\u201310 days pi to become undetectable after 30 days pi, except for a transient viral recovery from salivary gland. Virus was undetectable by coculture at 365 and 540 days pi.<\/jats:p><jats:p>No immunoglobulins or C<jats:sub>3<\/jats:sub> deposits were detected by immunofluorescence in brain or kidney at any stage, and histologic lesions were absent throughout. Anti\u2010Tacaribe and anti\u2010Jun\u00edn neutralizing Abs were detected up to 660 days and full protection against challenge was achieved at 365 and 540 days, declining to 33% at 660 days pi. The results warrant consideration of Tacaribe virus as potential heterologous vaccine against Argentine hemorrhagic fever.<\/jats:p>","DOI":"10.1002\/jmv.1890230308","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T13:39:26Z","timestamp":1172842766000},"page":"257-263","source":"Crossref","is-referenced-by-count":16,"title":["Tacaribe virus: A new alternative for Argentine hemorrhagic fever vaccine"],"prefix":"10.1002","volume":"23","author":[{"given":"Guadalupe","family":"Carballal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Calello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rub\u00e9n P.","family":"Laguens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes C.","family":"Weissenbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"408","article-title":"Tratarniento con suero inmune de primates infectados con virus Junin. 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