{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T06:37:11Z","timestamp":1698043031726},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":6550,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cell\u2010mediated and humoral immune responses to human papillomavirus (HPV) were tested in groups of patients with various degrees of cervical intraepithelial neoplasia (CIN) using a lymphocyte proliferation assay (LPA) as a measure of circulating sensitised T\u2010cells and an enzyme\u2010linked immunosorbent assay (ELISA) for antibodies.<\/jats:p><jats:p>Twenty\u2010three of 92 patients (25%) gave stimulation indices (S.I.) greater than two to at least one of the several antigen preparations tested in the LPA. Of 282 patients, 144 (50.1%) showed ELISA indices (E.I.) greater than one to HPV\u20101 and\/or HPV\u20102 antigens prepared by disruption of purified virions.<\/jats:p><jats:p>No correlation was found between positive responses in either test and the presence in cervical biopsies of koilocytes (considered pathognomonic for HPV infections), or between positive responses and the degree of dysplasia observed. Rather, positive antibody and T\u2010cell responses corresponded with a history of past or present skin warts. Although antibody was detected in 42\/86 (48.8%) women who thought they had never had warts, only 2\/24 (8.3%) with no known history gave a positive S.I. in LPA.<\/jats:p>","DOI":"10.1002\/jmv.1890240111","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T13:49:51Z","timestamp":1172843391000},"page":"85-95","source":"Crossref","is-referenced-by-count":12,"title":["Humoral and cellular immunity to papillomavirus in patients with cervical dysplasia"],"prefix":"10.1002","volume":"24","author":[{"given":"Heather A.","family":"Cubie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Norval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90006-5"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.32.2.122"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400022531"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/j.1460-2075.1986.tb04219.x","article-title":"Identification of the human papilloma virus\u2010Ia E4 gene products","volume":"5","author":"Doorbar J","year":"1986","journal-title":"The EMBO Journal"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890170305"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/jcm.9.6.657-664.1979","article-title":"Antigen requirements, sensitivity and specificity of enzyme immunoassays for measles and rubella viral antibodies","volume":"9","author":"Forghani B","year":"1979","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.4.1310"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(85)90056-2"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"26S","DOI":"10.1038\/jid.1984.16","article-title":"Presence of human papillomavirus in genital tumours","volume":"83","author":"Gissmann L","year":"1984","journal-title":"Journal of Investigative Dermatology"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1976.tb05140.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00201955"},{"key":"e_1_2_1_13_1","first-page":"495","article-title":"Immunological relatedness of papillomaviruses from different species","volume":"64","author":"Jenson AB","year":"1980","journal-title":"Journal of the National Cancer Institute"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(85)90059-8"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1956.tb32134.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1128\/mr.46.2.191-207.1982","article-title":"Animal Papillomaviruses","volume":"46","author":"Lancaster WD","year":"1982","journal-title":"Microbiological Reviews"},{"key":"e_1_2_1_17_1","first-page":"419","article-title":"Cell\u2010mediated immunity (CMI) to human wart virus and wart\u2010associated tissue antigens","volume":"26","author":"Lee AKY","year":"1976","journal-title":"Clinical and Experimental Immunology"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91478-5"},{"key":"e_1_2_1_19_1","first-page":"379","article-title":"Condylomatous lesion of the cervix II. 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