{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:09:28Z","timestamp":1780614568855,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":6459,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1988,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Enteric virus infections were studied in two children with congenital T\u2010cell immunode\u2010ficiency. One patient (LC) with cartilage hair hypoplasia developed persistent diarrhea and malabsorption following acute gastroenteritis. Electron microscope (EM) examination of feces revealed excretion of rotavirus for more than 450 days with concurrent astrovirus infection for at least 225 days, associated with the persistent diarrhea. Prolonged infection with poliovirus type 2 following vaccination had previously been noted in this patient. The second patient (DT), with the CHARGE association and DiGeorge syndrome, had two episodes of loose stools. EM of fecal extracts demonstrated rotavirus excretion for at least 66 days following the initial episode.<\/jats:p><jats:p>Virus\u2010specific immune responses were assayed in these two patients. LC showed a poor serum neutralizing antibody response to poliovaccination, no detectable antibody response (by immune EM and ELISA) to rotavirus, and no detectable antibody response to astrovirus (by immune EM). Rotavirus specific cell mediated immunity was also not detectable. DT showed no detectable serum antibody response to rotavirus (by ELISA). Rotavirus isolates from both patients were found to be group A viruses and were further analyzed by polyacrylamide gel electrophoresis. Atypical genome profiles, with multiple additional bands between segments 3\u20137 of the normal rotavirus profile, were obtained throughout the course of each illness, including the earliest specimens available (day 41, LC; day 7, DT).<\/jats:p><jats:p>These results indicate that chronic virus infection of the gut can occur in patients with T\u2010cell immunodeficiency. Such chronic infection may be associated with persistent diarrhea and can cause considerable problems of management.<\/jats:p>","DOI":"10.1002\/jmv.1890240410","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T16:14:01Z","timestamp":1172852041000},"page":"435-444","source":"Crossref","is-referenced-by-count":77,"title":["Chronic enteric virus infection in two T\u2010cell immunodeficient children"],"prefix":"10.1002","volume":"24","author":[{"given":"D. J.","family":"Wood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. L.","family":"Chrystie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Totterdell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1985.tb10069.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107688607900216"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01315311"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441216"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91005-4"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1128\/mr.48.2.157-179.1984","article-title":"Human viral gastroenteritis","volume":"48","author":"Cukor G","year":"1984","journal-title":"Microbiological Reviews"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1986.tb01258.x"},{"issue":"5","key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1128\/jcm.21.5.753-758.1985","article-title":"Epidemiology of rotavirus electropherotypes determined by a simplified diagnostic technique with RNA analysis","volume":"21","author":"Dolan KT","year":"1985","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198511000-00007"},{"issue":"2","key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1128\/jvi.57.2.706-708.1986","article-title":"T\u2010cell\u2010deficient mice display normal recovery from experimental rotavirus infection","volume":"57","author":"Eiden J","year":"1986","journal-title":"Journal of Virology"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400064238"},{"key":"e_1_2_1_13_1","first-page":"143","volume-title":"Immunoenzymatic Assay Techniques: Development in Clinical Biochemistry","author":"Graubelle PC","year":"1980"},{"key":"e_1_2_1_14_1","first-page":"349","article-title":"Rotavirus infections in newborns: An epidemiological and clinical study","volume":"17","author":"Grillner L","year":"1985","journal-title":"Scandinavian Journal of Infectious Diseases"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(85)90099-6"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-65-7-1141"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80131-4"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80216-2"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/137.6.810"},{"key":"e_1_2_1_20_1","unstructured":"TotterdellB(1988):Biophysical characterisation of rotavirus particles containing rearranged genomes. Journal of Medical Virology (in press)."}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890240410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890240410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T23:27:34Z","timestamp":1697844454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890240410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,4]]}},"alternative-id":["10.1002\/jmv.1890240410"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890240410","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,4]]}}}