{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T06:41:10Z","timestamp":1770014470478,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":6306,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Junin virus, the etiological agent of Argentine hemorrhagic fever, produces in man a disease mainly characterized by hemorrhagic alterations, commonly accompanied by neurological symptoms, and leading to 10% mortality. Intracerebral inoculation in 10\u2010day\u2010old rats or intraperitoneal inoculation in 2\u2010day\u2010old rats leads to high mortality due to severe encephalitis. Here, the effect of Ribavirin on these experimental models was tested in order to evaluate the degree of protection achieved against neuropathological manifestations. In intracerebrally infected 10\u2010day\u2010old rats the drug was administered 2 hr before virus inoculation. Doses ranged from 30 to 90 mg\/kg body weight. Protection reached 40% for the 60 and 90 mg doses. Intraperitoneally infected 2\u2010day\u2010old rats received the drug in five 30\u2010mg daily doses, starting the same day as virus inoculation. Survival was 73%. Viral replication within peritoneal macrophages dropped markedly, leading to much lower CNS viral titres. Together with results reported in primates, our findings support further studies on Ribavirin, with a view to eventual trials in humans.<\/jats:p>","DOI":"10.1002\/jmv.1890260111","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T16:26:57Z","timestamp":1172852817000},"page":"79-84","source":"Crossref","is-referenced-by-count":8,"title":["Ribavirin effect on experimental Junin virus\u2010induced encephalitis"],"prefix":"10.1002","volume":"26","author":[{"given":"Mirta C.","family":"Remesar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorgelina L.","family":"Blejer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes C.","family":"Weissenbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta R.","family":"Nejamkis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1107","article-title":"CNS involvement following intraperitoneal inoculation of rats with Junin virus","volume":"13","author":"Blejer JL","year":"1985","journal-title":"IRCS Medical Science"},{"key":"e_1_2_1_3_1","first-page":"484","article-title":"Action of antithymocyte serum on Junin virus infection in rats","volume":"27","author":"Blejer JL","year":"1983","journal-title":"Acta Virologica"},{"key":"e_1_2_1_4_1","first-page":"898","article-title":"Modelo rata virus Junin: Indicador de virulencia","volume":"43","author":"Blejer JL","year":"1983","journal-title":"Medicina (Buenos Aires)"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.3.478"},{"key":"e_1_2_1_6_1","first-page":"18","article-title":"Un nuevo ensayo de placas para la cuantificacion del virus Jun\u00edn","volume":"13","author":"Giovanniello OA","year":"1981","journal-title":"Revista Argentina de Microbiologia"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(73)90174-3"},{"key":"e_1_2_1_8_1","first-page":"49","volume-title":"Clinical Applications of Ribavirin","author":"Huggins JW","year":"1984"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/153.3.489"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/141.5.580"},{"key":"e_1_2_1_11_1","first-page":"391","article-title":"Infecci\u00f3n cr\u00f3nica con virus Jun\u00edn en la rata. Estudios pat\u00f3logicos y virol\u00f3gicos","volume":"43","author":"Laguens RP","year":"1983","journal-title":"Medicina (Buenos Aires)"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890190111"},{"key":"e_1_2_1_13_1","first-page":"889","volume-title":"Progress in Chemotherapy","author":"Sidwell RW","year":"1974"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890200308"},{"key":"e_1_2_1_15_1","first-page":"79","article-title":"Argentine hemorrhagic fever","volume":"134","author":"Weissenbacher MC","year":"1986","journal-title":"Current Topics in Microbiology and Immunology"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890260111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890260111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T13:55:04Z","timestamp":1697896504000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890260111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["10.1002\/jmv.1890260111"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890260111","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9]]}}}