{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:14:42Z","timestamp":1790712882272,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":6247,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1988,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a large population of patients, chronic hepatitis delta virus (HDV) infection was usually associated with absence of hepatitis B virus (HBV) replication. However, acute HDV superinfection progressing to chronic HDV infection in two hepatitis B e antigen (HBeAg)\u2010positive HBV carriers and coinfection in two other patients who progressed to chronic HBV (HBeAg\u2010positive) and HDV infection was associated with continuing high\u2010level HBV replication for several years. Thus HDV infection does not always inhibit HBV replication. The hypothesis that the different effects of HDV coinfection and superinfection on HBV replication may stem from variability in the capacity of the host to produce and respond to interferon is discussed.<\/jats:p>","DOI":"10.1002\/jmv.1890260308","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T16:24:54Z","timestamp":1172852694000},"page":"279-288","source":"Crossref","is-referenced-by-count":16,"title":["Acute and chronic hepatitis delta virus infection: Direct or indirect effect on hepatitis B virus replication?"],"prefix":"10.1002","volume":"26","author":[{"given":"Patrizia","family":"Farci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Karayiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Eliana","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Marongiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Orgiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Balestrieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard C.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"914","article-title":"Acute and chronic hepatitis revisited","volume":"2","author":"Bianchi L","year":"1977","journal-title":"Lancet"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.22.8774"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.1.4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.255.11.1443"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(82)90042-4"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/14.4.291"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890140408"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030505"},{"key":"e_1_2_1_10_1","first-page":"291","volume-title":"The Hepatitis Delta Virus and Its Infection","author":"Hoofnagle JH","year":"1987"},{"key":"e_1_2_1_11_1","first-page":"91","volume-title":"Viral Hepatitis and Delta Infection","author":"Hoyer W","year":"1983"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840060525"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.12.1498"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(85)80759-5"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.25.11.1283"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840060303"},{"key":"e_1_2_1_17_1","first-page":"773","article-title":"Immunoperoxidase staining of the HBV\u2010associated delta antigen in paraffinated liver specimens","volume":"73","author":"Recchia S","year":"1981","journal-title":"Pathologica"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030518"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/141.5.590"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.4049\/jimmunol.125.1.318","article-title":"The hepatitis B virus\u2010associated delta antigen: Isolation from liver, development of solid phase radioimmunoassays for delta and anti\u2010delta and partial characterization of delta antigen","volume":"125","author":"Rizzetto M","year":"1980","journal-title":"Journal of Immunology"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(85)80766-2"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-4-437"},{"key":"e_1_2_1_23_1","first-page":"299","volume-title":"The Hepatitis Delta Virus and Its Infection","author":"Rosina F","year":"1987"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890090208"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/18.5.315"},{"key":"e_1_2_1_26_1","first-page":"277","volume-title":"The Hepatitis Delta Virus and Its Infection","author":"Thomas HC","year":"1987"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890090405"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890260308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890260308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T15:10:06Z","timestamp":1697901006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890260308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,11]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,11]]}},"alternative-id":["10.1002\/jmv.1890260308"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890260308","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,11]]}}}