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T\u2010cell suppressor activity was in the normal range in healthy carriers and in patients negative for serum HBV\u2010DNA, independent of the e antigen status. In contrast, the group of patients positive for HBV\u2010DNA exhibited a significant reduction in suppressor activity. Longitudinal studies in patients who cleared serum HBV\u2010DNA demonstrated that suppressor T\u2010cell activity became normal thereafter. These results suggest a relationship between suppressor T\u2010cell function and the stage of viral replication in individuals with chronic HBV infection.<\/jats:p>","DOI":"10.1002\/jmv.1890270109","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T16:30:39Z","timestamp":1172853039000},"page":"39-43","source":"Crossref","is-referenced-by-count":3,"title":["Suppressor T\u2010cell activity in chronic hepatitis B\u2010virus infection: Relationship with the presence of HBV\u2010DNA in serum"],"prefix":"10.1002","volume":"27","author":[{"given":"Margarita","family":"Iraburu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Pilar","family":"Civeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Morte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Castilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/0016-5085(78)90472-9","article-title":"Full and empty Dane particles in chronic hepatitis B virus infection: Relation to hepatitis B e antigen and presence of liver damage","volume":"75","author":"Alberti A","year":"1978","journal-title":"Gastroenterology"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92410-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.12.3808"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/0016-5085(81)90075-5","article-title":"Adenine\u2010arabinoside therapy in HBsAg positive chronic liver disease: a controlled study","volume":"80","author":"Bassendine MF","year":"1981","journal-title":"Gastroenterology"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4049\/jimmunol.126.1.38","article-title":"Functional properties of lymphocyte subpopulations in hepatitis B virus infection. 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