{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:05:46Z","timestamp":1790622346616,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":6153,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1989,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral blood lymphocyte subpopulations were studied in 15 patients with Argentine Hemorrhagic Fever (AHF), during the acute period of the disease and in early convalescence. Antihuman lg antibodies were used to identify B cells and monoclonal antibodies to assess T4 and T8 subsets. During the acute period of the disease, significant alterations were found in B, T4, and T8 lymphocytes (<jats:italic>P<\/jats:italic> &lt; 0.001), as well as in T4\/T8 ratios (<jats:italic>P<\/jats:italic> &lt; 0.001). These abnormalities disappeared in early convalescence, around 30 days after the clinical onset. Diminished numbers of T4 lymphocytes are interpreted as relevant to the immunodepression that characterizes the acute phase of AHF.<\/jats:p>","DOI":"10.1002\/jmv.1890270218","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T16:29:58Z","timestamp":1172852998000},"page":"160-163","source":"Crossref","is-referenced-by-count":18,"title":["Lymphocyte subsets alteration in patients with argentine hemorrhagic fever"],"prefix":"10.1002","volume":"27","author":[{"given":"Daniel A.","family":"Vallejos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Ambrosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda R.","family":"Feuillade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio I.","family":"Maiztegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000149662"},{"key":"e_1_2_1_3_1","first-page":"129","volume-title":"Statical Methods in Medical Research","author":"Penley KA","year":"1980"},{"issue":"3","key":"e_1_2_1_4_1","first-page":"186","article-title":"Estudios inmunol\u00f3gicos en la fiebre hemorr\u00e1gica argentina","volume":"37","author":"Arana R","year":"1977","journal-title":"Medicina (Buenos Aires)"},{"issue":"97","key":"e_1_2_1_5_1","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood","volume":"21","author":"Penley KA","year":"1968","journal-title":"The Scandinavian Journal of Clinical and Laboratory Investigation"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1128\/iai.34.2.323-327.1981","article-title":"Cell mediated immunity and lymphocytic population in experimental Argentine hemorrhagic fever (Junin virus)","volume":"34","author":"Carballal G","year":"1981","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/135.3.367"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90299-X"},{"key":"e_1_2_1_9_1","unstructured":"EnriaD ContiO MaizteguiJI(1984b):Efecto regulatorio del plasma inmune sobre la inmunidad mediada por c\u00e9lulas en enfermos de FHA. 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