{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T05:46:41Z","timestamp":1762926401094},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":6125,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The levels of Varicella\u2010zoster virus (VZV)\u2010specific IgG, IgM, and IgA antibodies produced in 22 cases of varicella, 22 cases of cutaneous zoster, and 12 cases of acute aseptic meningitis due to VZV in the absence of cutaneous lesions, were measured by indirect enzyme immunoassay (EIA) and compared with those observed in a group of 34 age\u2010matched controls. The definition of cutoff titres for each serological marker and combinations of them allowed early diagnosis of infection in 82% of varicella patients and 91% of patients with acute aseptic meningitis lacking cutaneous lesions on a single serum sample, the specificity being over 90%. The system was as sensitive as the demonstration of intrathecally produced IgG antibodies for the early diagnosis of the infection in 22 cases of neurological disease due to VZV. A working protocol for the serological diagnosis of VZV infections, using currently available EIA reagents, is described.<\/jats:p>","DOI":"10.1002\/jmv.1890270308","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T16:39:56Z","timestamp":1172853596000},"page":"224-230","source":"Crossref","is-referenced-by-count":12,"title":["Definition of high\u2010proficiency serological markers for diagnosis of Varicella\u2010zoster virus infections by enzyme immunoassay"],"prefix":"10.1002","volume":"27","author":[{"given":"Jos\u00e9 M.","family":"Echevarr\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"de Ory","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"T\u00e9llez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1128\/iai.38.2.399-407.1982","article-title":"Intrathecal synthesis of virus antibodies in multiple sclerosis patients","volume":"38","author":"Arnadottir T","year":"1982","journal-title":"Infection and Immunity (Washington)"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1128\/jcm.12.3.367-374.1980","article-title":"Immunoglobulins M and G to Varicella\u2010zoster virus measured by solid\u2010phase radioimmunoassay: Antibody responses to varicella and herpes zoster infections","volume":"12","author":"Arvin AM","year":"1980","journal-title":"Journal of Clinical Microbiology (Washington)"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/148.2.200"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400025730"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.5.959"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1128\/jcm.19.5.606-609.1984","article-title":"Antibody class capture assays for Varicella\u2010zoster virus","volume":"19","author":"Forghani B","year":"1984","journal-title":"Journal of Clinical Microbiology (Washington)"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1128\/jcm.12.6.764-767.1980","article-title":"Varicellazoster\u2010associated encephalitis: Detection of specific antibody in cerebrospinal fluid","volume":"12","author":"Gershon A","year":"1980","journal-title":"Journal of Clinical Microbiology (Washington)"},{"key":"e_1_2_1_9_1","volume-title":"Diagnostic Methods in Clinical Virology","author":"Grist NR","year":"1974"},{"key":"e_1_2_1_10_1","first-page":"1433","article-title":"Clusters of shingles (Letter)","volume":"2","author":"Mart\u00ednez\u2010Mart\u00edn P","year":"1985","journal-title":"Lancet (London)"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890160213"},{"key":"e_1_2_1_12_1","first-page":"387","volume-title":"The Human Herpes Viruses. 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