{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T10:42:06Z","timestamp":1707648126467},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":6007,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1989,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Virus\u2010like particles (60\u201370 nm) with spiked surfaces budding into cell vacuoles and rod\u2010shaped inclusions were detected in nuclei of hepatocytes from a British patient transplanted for sporadic non\u2010A, non\u2010B fulminant hepatitis (NANBFHF), probably contracted in Kenya. Identical particles were seen in two successive grafts (days 2 and 10) at regrafting for recurrent FHF. Ultrastructural features resembled those of the RNA\u2010containing arbovirus, Rift Valley fever virus, but serological markers against a representative panel for arboviruses (Togaviruses) and transmission in mice proved negative. The particles shared features with the different arboviruses seen in the hepatectomy specimen of a second patient with NANB\u2010FHF, and in both patients an insect vector was implicated in the clinical history. The particles were identical in size to those of a third patient with NANB\u2010FHF, who had remained in the United Kingdom. These findings, together with the recent report of isolation of an RNA\u2010containing virus resembling the Togaviridae, in parenteral NANB, suggest that several exotic virus\u2010like agents resembling the arboviruses may be involved in the aetiology of NANB, including in the sporadic forms of FHF in the United Kingdom.<\/jats:p>","DOI":"10.1002\/jmv.1890280308","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T16:57:37Z","timestamp":1172854657000},"page":"150-155","source":"Crossref","is-referenced-by-count":25,"title":["Toga\u2010Like virus as a cause of fulminant hepatitis attributed to sporadic non\u2010a, non\u2010b"],"prefix":"10.1002","volume":"28","author":[{"given":"Elizabeth A.","family":"Fagan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Portmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George M.","family":"Tovey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie J.","family":"Zuckerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90131-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)18852-5"},{"key":"e_1_2_1_4_1","first-page":"210","article-title":"Aetiological association of a viruslike particle with enterically transmitted non\u2010A, non\u2010B hepatitis in experimentally infected chimpanzees","volume":"143","author":"Arankalle VA","year":"1988","journal-title":"Journal of Infectious Diseases"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-42-2-329"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890240205"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890220211"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890270116"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.12.1194"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/145.6.854"},{"key":"e_1_2_1_11_1","unstructured":"HoughtonM(1989): Parenteral non\u2010A non\u2010B virus: Molecular isolation and immunity. In \u201cProceedings of the 23rd Meeting of the European Association for the Study of the Liver August 1988.\u201dJournal of Hepatology Supplement (in press)."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040665"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890160106"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040628"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890110308"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.4269\/ajtmh.1978.27.1216","article-title":"Dengue fever with haemorrhagic manifestations: A report of 3 cases from Puerto Rico","volume":"27","author":"Lopez\u2010Correa RH","year":"1978","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.1.72"},{"key":"e_1_2_1_18_1","first-page":"325","article-title":"A study of the ultrastructural alterations in experimental non\u2010A, non\u2010B hepatitis by electron beam analysis","volume":"63","author":"McCaul TF","year":"1982","journal-title":"British Journal of Experimental Pathology"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890140411"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1440-1827.1984.tb07601.x","article-title":"A pathological study of fulminant liver disease","volume":"34","author":"Mori W","year":"1984","journal-title":"Acta Pathologica Japan"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91509-5"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.451589"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-25-3950"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90132-0"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91808-7"},{"key":"e_1_2_1_26_1","first-page":"41","article-title":"Ultrastructural changes in the liver in experimental non\u2010A, non\u2010B hepatitis","volume":"62","author":"Tsiquaye KN","year":"1981","journal-title":"British Journal of Experimental Pathology"},{"key":"e_1_2_1_27_1","first-page":"286","article-title":"Liver transplantation: The initial experience of a Canadian centre","volume":"28","author":"Wall WJ","year":"1985","journal-title":"Canadian Journal of Surgery"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840040410"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)90945-0"},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0016-5085(80)90377-7","article-title":"Virus\u2010like particles in a plasma fraction (fibrinogen) and in the circulation of apparently healthy blood donors capable of inducing non\u2010A\/non\u2010B hepatitis in humans and chimpanzees","volume":"79","author":"Yoshizawa H","year":"1980","journal-title":"Gastroenterology"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890280308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890280308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T10:26:25Z","timestamp":1707647185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890280308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,7]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,7]]}},"alternative-id":["10.1002\/jmv.1890280308"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890280308","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,7]]}}}