{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:04:59Z","timestamp":1792285499534,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5943,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To elucidate the effects of pregnancy and delivery on hepatitis B e antigen (HBeAg)\u2010positive carrier mothers, 31 HBeAg\u2010positive carrier mothers were followed\u2010up postpartum 1 year, with 30 HBeAg\u2010positive nonpregnant female carriers as controls. Serum hepatitis B surface antigen (HBsAg), HBeAg titer, and hepatitis B virus (HBV)\u2010DNA concentration were studied at defined intervals. The results revealed that in the control group HBeAg titers and HBV\u2010DNA concentrations fluctuated, whereas the HBsAg titers showed little change, but HBeAg clearance or seroconversion to anti\u2010HBe were not noted on follow\u2010up. In contrast, one carrier mother sero\u2010converted to anti\u2010HBe during pregnancy and the antibody persisted thereafter. Five of the remaining 30 carrier mothers cleared HBeAg postpartum, and among these five cases, one also seroconverted to anti\u2010HBe. In addition, in another five of the 30 cases, the HBV\u2010DNA fell to undetectable level (&lt; 0.04 ng\/ml). All these ten cases had a common tendency of showing a decrease in HBeAg titers and\/or HBV\u2010DNA concentrations 1\u20132 months after delivery. The HBeAg titers and HBV\u2010DNA concentrations in the other 11 cases remained unchanged, whereas the remaining nine cases had increased levels. It is concluded that subsidence of HBV replication is precipitated by delivery in one\u2010third of HBeAg\u2010positive carrier mothers in Taiwan, and this occurs most frequently 1\u20132 months postpartum.<\/jats:p>","DOI":"10.1002\/jmv.1890290102","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T17:26:06Z","timestamp":1172856366000},"page":"1-6","source":"Crossref","is-referenced-by-count":49,"title":["Postpartum subsidence of hepatitis B viral replication in hbeag\u2010positive carrier mothers"],"prefix":"10.1002","volume":"29","author":[{"given":"Ho\u2010Hsiung","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Jer","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding\u2010Shinn","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juei\u2010Low","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kung\u2010Ho","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiang\u2010Chin","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Sen","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Yao","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90624-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112370"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1001\/jama.1987.03390190075023","article-title":"A mass vaccination program in Taiwan against hepatitis B virus infection in infants of hepatitis B surface antigen\u2010carrier mothers","volume":"257","author":"Chen DS","year":"1987","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1987.tb00162.x"},{"key":"e_1_2_1_6_1","first-page":"686","article-title":"Pregnancy outcome in woman with systemic lupus erythematosus","volume":"63","author":"Gimovsky ML","year":"1984","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-94-6-744"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(74)90090-8"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.2957\/kanzo.25.1513"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.2957\/kanzo.25.1394"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(83)80114-0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80210-X"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840060616"},{"key":"e_1_2_1_14_1","first-page":"173","volume-title":"Advances in Viral Oncology","author":"Nishioka K","year":"1985"},{"key":"e_1_2_1_15_1","first-page":"14","article-title":"Changes in human serum corticosterone and cortisol during pregnancy, labor and delivery","volume":"40","author":"Noguchi M","year":"1988","journal-title":"Acta Obstetrica et Gynecologica Japonica"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-51-3-466"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197604012941402"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.2957\/kanzo.26.20"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-197904020-00004"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198309000-00010"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/0002-9378(79)90743-9","article-title":"Unbound cortisol in umbilical cord plasma and maternal plasma: A reinvestigation","volume":"135","author":"Predine J","year":"1979","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"e_1_2_1_22_1","first-page":"155","volume-title":"Hepatitis B","author":"Sampliner RE","year":"1985"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030301"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890030310"},{"key":"e_1_2_1_25_1","first-page":"40","article-title":"Hepatocellular carcinoma and the hepatitis B virus: Evidence for a causal association","volume":"27","author":"Szmuness W","year":"1978","journal-title":"Progress in Medical Virology"},{"key":"e_1_2_1_26_1","first-page":"24","article-title":"Influence of pregnancy on hepatitis B virus carriers","volume":"39","author":"Tagawa H","year":"1987","journal-title":"Acta Obstetrica et Gynecologica Japonica"},{"key":"e_1_2_1_27_1","first-page":"1010","article-title":"Effect of pregnancy and delivery in HBe antigen positive carrier (in Japanese)","volume":"76","author":"Tashima H","year":"1987","journal-title":"Acta Medicine Japonica"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6367.750"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(83)90862-1"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92388-2"},{"key":"e_1_2_1_31_1","first-page":"1104","volume-title":"Viral Hepatitis and Liver Disease","author":"Zuckerman AJ","year":"1988"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890290102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890290102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T09:35:08Z","timestamp":1697967308000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890290102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,9]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,9]]}},"alternative-id":["10.1002\/jmv.1890290102"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890290102","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,9]]}}}