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To investigate whether certain of these other viruses might have an effect on the ability of the human immunodeficiency virus type 1 (HIV\u20101) to replicate, we coincubated peripheral blood mononuclear cells (PBMC) from nine HIV\u20101\u2010seropositive donors with live preparations of various herpes viruses. In seven of nine cases, exposure of PBMC to preparations of either HSV\u20101, HSV\u20102, or CMV stimulated the cells to become active producers of HIV\u20101, as determined by reverse transcriptase activity and by the presence of infectious progeny virus. This increased production of HIV\u20101 particles appeared to be a consequence of mitogenic proliferation and of herpes virus\u2010encoded transacting factors. These results supplement earlier findings on the molecular activation of the HIV\u20101 genome by both HSV and CMV genetic elements and point to a possible role for these viruses in the pathogenesis and ultimate clinical outcome of HIV\u20101 infections.<\/jats:p>","DOI":"10.1002\/jmv.1890290207","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T17:23:48Z","timestamp":1172856228000},"page":"109-114","source":"Crossref","is-referenced-by-count":16,"title":["Active replication of human immunodeficiency virus type 1 by peripheral blood mononuclear cells following coincubation with herpes viruses"],"prefix":"10.1002","volume":"29","author":[{"given":"Michel","family":"Tremblay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervyn","family":"Gornitsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark 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