{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:17:21Z","timestamp":1766135841198},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5913,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Six monoclonal antibodies (McAbs) against Japanese encephalitis virus (JEV) were tested for passive protection in JEV\u2010infected mice, goats, and rhesus monkeys. mG9 and nG2 had no protective effect; mG3 and 2D2 had some protective effect, but not sufficient to be of therapeutic significance; and 2H4 and 2F2 had excellent protective efficacy in mice even 120 hr after infection when most of the mice in the virus control group were sick. The mixture of 2H4, 2F2, mC3 (M\u2010McAb), and their F(ab')2 fragments showed excellent protection in mice, goats, and monkeys and was safe. The protective effects of McAbs correlated with their neutralization titers, but cytotoxicity\u2010mediated activities also played a role in protection.<\/jats:p>","DOI":"10.1002\/jmv.1890290211","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T17:23:48Z","timestamp":1172856228000},"page":"133-138","source":"Crossref","is-referenced-by-count":46,"title":["Passive protection of mice, goats, and monkeys against Japanese encephalitis with monoclonal antibodies"],"prefix":"10.1002","volume":"29","author":[{"given":"Mingjie","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meixan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaozhun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"issue":"2","key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1128\/jvi.54.2.546-551.1985","article-title":"Mechanisms of monoclonal antibody\u2010medicated protection against virulent semliki forest virus","volume":"54","author":"Boere WAM","year":"1985","journal-title":"Journal of Virology"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-64-6-1405"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/151.6.1093"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-67-6-963"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(87)90076-7"},{"key":"e_1_2_1_7_1","first-page":"228","volume-title":"Diagnostic Procedure for Viral and Rickettsial Infections","author":"Hammon WM","year":"1969"},{"key":"e_1_2_1_8_1","first-page":"270","volume-title":"Principles and Practice of Infectious Diseases","author":"Hayden FG","year":"1985"},{"issue":"3","key":"e_1_2_1_9_1","first-page":"234","article-title":"Detection of JEV antigen by ELISA: III. 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