{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:00:22Z","timestamp":1698037222541},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5913,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Administration of cyclophosphamide (CY) to guinea pigs infected with a lethal strain of Junin virus (JV) delayed the time of death, with survival of a small number of animals. Virological studies showed a temporary decrease of virus concentration in blood and viscera shortly after the CY injection. In the pathological study no differences were found in the organic lesions present in CY\u2010treated and nontreated animals, with the exception of the pulmonary alterations. In CY\u2010treated guinea pigs the lungs appeared almost normal, but in the control. nontreated animals severe alterations with the pattern of the \u201crespiratory distress syndrome of the adult\u201d were consistently present. In in vitro experiments, incorporation of serum collected from guinea pigs injected 30 minutes before exsanguination with CY to cell cultures, infected with JV, prevented virus replication. On the basis of these results it is suggested that the delay of time of death and eventual survival of CY\u2010treated guinea pigs after JV infection depends on a direct antiviral effect of the drug rather than on its known immunosuppressive action. In addition, the absence of pulmonary alterations in CY\u2010treated animals was tentatively considered to be dependent on the marked polymorphonu\u2010clear leukocyte depletion induced by the drug.<\/jats:p>","DOI":"10.1002\/jmv.1890290213","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T17:23:48Z","timestamp":1172856228000},"page":"146-151","source":"Crossref","is-referenced-by-count":2,"title":["Protective effect of a low\u2010dose of cyclophosphamide in experimental infection of guinea pigs with junin virus"],"prefix":"10.1002","volume":"29","author":[{"given":"Carlos","family":"Ponzinibbio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben 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