{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:09:07Z","timestamp":1784192947906,"version":"3.55.0"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5913,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Foscarnet (trisodium phosphonoformate) is a novel antiviral agent that inhibits viral\u2010specific DNA polymerase. In the present study, eight males with chronic HBV carriage (HBeAg and HBV\u2010DNA seropositivity &gt; 12 months) showing chronic persistent hepatitis (CPH) or chronic active hepatitis (CAH) on liver biopsy received either a continuous infusion of foscarnet at 0.15 mg\/kg\/min for 7 days or 180 mg\/kg\/day divided into three daily boluses for 2 weeks. In all eight, HBV\u2010DNA levels fell during therapy (median, 401 pg\/40 \u03bcl serum; range, 4\u20133, 100) vs. pretreatment levels (median, 533 pg\/40 \u03bcl; range, 30\u20134, 175), but in none was HBV\u2010DNA undetectable at any stage. Within 1 month, the HBV\u2010DNA had risen to pretreatment levels in all but one patient (with the lowest pretreatment level), who cleared HBeAg and developed anti\u2010HBe within 3 months. Two further patients were anti\u2010HBe positive at 6 months, but their pretreatment serum HBV\u2010DNA levels were already low, suggesting a high probability of spontaneous seroconversion. Toxicity was not evident with the continuous infusion, but for those receiving IV bolus therapy, serum creatinine and phosphate levels rose in three of four patients, necessitating a 25% dose reduction. There was no difference in the effect on serum HBV\u2010DNA between the two regimes. We conclude that foscarnet has only modest antiviral activity in chronic HBV carriers.<\/jats:p>","DOI":"10.1002\/jmv.1890290214","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T17:23:48Z","timestamp":1172856228000},"page":"152-155","source":"Crossref","is-referenced-by-count":25,"title":["Foscarnet therapy in chronic hepatitis B virus e antigen carriers"],"prefix":"10.1002","volume":"29","author":[{"given":"V. G.","family":"Bain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M.","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chanas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. J. M.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92735-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(86)80104-0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840060537"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840050406"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(85)90136-3"},{"key":"e_1_2_1_7_1","first-page":"947","volume-title":"Viral Hepatitis and Liver Disease","author":"Hedin G","year":"1988"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840050612"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(82)90074-2"},{"key":"e_1_2_1_10_1","first-page":"532","volume-title":"Viral Hepatitis and Liver Disease","author":"Sherker AH","year":"1988"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890290214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890290214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T06:47:34Z","timestamp":1697957254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890290214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,10]]}},"alternative-id":["10.1002\/jmv.1890290214"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890290214","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,10]]}}}