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Its behavior in vivo is not yet well studied. Using specific monoclonal antibodies for immunoblotting, we found an abundance of small surface protein in the serum of chronic virus carriers and moderate amounts in the liver irrespective of viremia. The large surface protein was present in the serum and the liver of viremic carriers. In nonviremic carriers, the large protein was absent from serum, but in the liver a shorter form of the large protein was readily detectable. These findings suggest a complex regulatory mechanism of the viral surface protein depending on the expression of other viral gene products.<\/jats:p>","DOI":"10.1002\/jmv.1890290408","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T17:34:30Z","timestamp":1172856870000},"page":"261-265","source":"Crossref","is-referenced-by-count":11,"title":["Immune blot analysis of viral surface proteins in serum and liver of patients with chronic hepatitis B virus infection"],"prefix":"10.1002","volume":"29","author":[{"given":"Guido","family":"Gerken","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Manns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram 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