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Of 49 babies immunised and successfully followed up, 43 (88%) became immune: 15 out of 21 (71%) of babies born to HBeAg+ mothers became immune, the other 6 becoming the only carrier babies in the study. Without immunisation a carrier rate in excess of 70% would have been expected in this high\u2010risk group. Vaccine alone, given in a rapid immunisation schedule, protected the majority of babies at risk. In those babies in whom the carrier state occurred in spite of immunisation, infection may have taken place in utero, or the infant may have failed to produce adequate antibody in response to the vaccine.<\/jats:p>","DOI":"10.1002\/jmv.1890300207","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T17:31:39Z","timestamp":1172856699000},"page":"113-116","source":"Crossref","is-referenced-by-count":23,"title":["Hepatitis B vaccine in the prevention of perinatally transmitted hepatitis B virus infection: Final report on a West Midlands pilot study"],"prefix":"10.1002","volume":"30","author":[{"given":"Susan M.","family":"Wheeley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth H.","family":"Boxall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Tarlow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rashid Gatrad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Bissenden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwei Cheong","family":"Chin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Mayne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/147.2.185"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030201"},{"key":"e_1_2_1_4_1","first-page":"172","volume-title":"Public Health Virology\u201012 Reports","author":"Boxall EH","year":"1986"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890180307"},{"issue":"6","key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1542\/peds.76.6.1020","article-title":"Hepatitis B immunoprophylaxis of low\u2010birth\u2010weight infants (Letter)","volume":"76","author":"Genesca J","year":"1985","journal-title":"Pediatrics"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90003-2"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890250407"},{"key":"e_1_2_1_9_1","first-page":"323","article-title":"Hepatitis B surface antigen testing: The Blood Products Laboratory Radio Immunoassay (BPL\/RIA) System","volume":"38","author":"Lane RS","year":"1981","journal-title":"Medical Laboratory Sciences."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92916-8"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91908-5"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.36.5.581"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890080206"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890300207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890300207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T19:15:11Z","timestamp":1698002111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890300207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,2]]}},"alternative-id":["10.1002\/jmv.1890300207"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890300207","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2]]}}}