{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T22:03:15Z","timestamp":1698098595064},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":5760,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Junin virus (JV), the etiological agent of Argentinian hemorrhagic fever, induces high mortality in the suckling BALB\/c mouse, which correlates with delayed\u2010type hypersensitivity (DTH)\u2010like immune response. In contrast, the adult mouse is resistant to infection, and no DTH response can be detected. An antigen\u2010nonspecific DTH suppressor T\u2010cell activity induced by JV has been described that may be related to adult mouse survival. In this report, we present evidence supporting the inability of such cells, identified here as bearing the L3T4 marker, to affect the normal establishment of a DTH reaction. In the same form, virus\u2010induced suppressor cells were unable to alter the expression of DTH effector cells in the absence of antigen\u2010specific DTH suppressor cells. Besides, we found that a single high dose (200 mg\/kg) of cyclophosphamide before or after JV inoculation was unable to alter the activity of virus\u2010induced suppressor cells.<\/jats:p>","DOI":"10.1002\/jmv.1890300308","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T18:15:11Z","timestamp":1172859311000},"page":"187-191","source":"Crossref","is-referenced-by-count":1,"title":["Junin virus\u2010induced suppressor cells are effective only on the efferent limb of the delayed\u2010type hypersensitivity response"],"prefix":"10.1002","volume":"30","author":[{"given":"Oscar E.","family":"Campetella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora V.","family":"Galassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hebe 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