{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:42:04Z","timestamp":1774125724328,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,11]],"date-time":"2005-12-11T00:00:00Z","timestamp":1134259200000},"content-version":"vor","delay-in-days":5733,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Children undergoing therapy for acute lymphoblastic leukaemia (ALL) are at increased risk of severe viral respiratory infection, and some find it difficult to terminate virus secretion. This increased severity may result from a defect in the mucosal immune response. To test this hypothesis, nasal immunoglobulin secretion and specific antiviral antibody responses to infection with respiratory syncytial (RS) virus in children with ALL have been compared with those in a normal age\u2010matched comparison group.<\/jats:p><jats:p>Children with leukaemia secreted normal levels of IgA and slightly raised lgM levels. lgG levels were depressed. Following RS virus infection, the majority of children with leukaemia secreted normal amounts of lgA and lgG nasal antibody and successfully cleared the virus. However, three of the 13 children studied made poor or undetectable nasal antibody responses, which correlated with their inability to clear the virus.<\/jats:p>","DOI":"10.1002\/jmv.1890300409","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T18:11:49Z","timestamp":1172859109000},"page":"277-281","source":"Crossref","is-referenced-by-count":11,"title":["Local antibody production and respiratory syncytial virus infection in children with leukaemia"],"prefix":"10.1002","volume":"30","author":[{"given":"C. E.","family":"Taylor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W.","family":"Craft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kernahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Millman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. L.","family":"Toms","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1984.tb03576.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.10.755"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.33.8.735"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb02962.x"},{"key":"e_1_2_1_6_1","volume-title":"Rapid Virus Diagnosis Application of Immunofluorescence","author":"Gardner PS","year":"1980"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1971)28:4<984::AID-CNCR2820280423>3.0.CO;2-C"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(74)80341-0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1182\/blood.V33.2.198.198","article-title":"The G\u2010immunoglobulins in acute leukaemia in children. Haematologic and Immunologic Relationships","volume":"33","author":"Kiran O","year":"1969","journal-title":"Blood"},{"key":"e_1_2_1_10_1","first-page":"275","article-title":"Quantitative composition of nasal secretions in normal subjects","volume":"80","author":"Lorin MI","year":"1972","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(65)90004-2"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(81)90122-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1128\/iai.23.2.276-281.1979","article-title":"Cell\u2010free and cell\u2010bound antibody in nasal secretions from infants with respiratory syncytial virus infection","volume":"23","author":"McIntosh K","year":"1979","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196510)18:10<1292::AID-CNCR2820181013>3.0.CO;2-L"},{"key":"e_1_2_1_15_1","first-page":"123","article-title":"Experimental mechanisms of resistance to infection and illness","volume":"107","author":"Mills J","year":"1971","journal-title":"Journal of Immunology"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb02241.x"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890140313"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.34.5.479"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105391"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.59.1.48"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.60.9.829"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.12.1656"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890300409","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890300409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T19:03:38Z","timestamp":1698001418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890300409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,4]]}},"alternative-id":["10.1002\/jmv.1890300409"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890300409","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,4]]}}}