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Lytic but also negative sera were found among HIV\u20101\u2010infected asymptomatic men as well as among clinical AIDS cases. Human antisera that lysed infected cells reacted similarly irrespective of whether the complement was heterologous or autologous. Analysis of complement\u2010mediated lysis using defined antisera against recombinant HIV\u20101 env or core antigens suggested that gp 160\/gp 120 and p24 can act as target antigens for an antibody\u2010 and complement\u2010mediated cytolysis of infected cells. Complement alone reduced the spread of HIV\u20101 infection in CD4<jats:sup>+<\/jats:sup> cells and the ability of HIV\u20101 and HIV\u20102 to form plaques in CD4\u2010transfected HeLa cells. Co\u2010operative effects of specific antibodies and complement were the most effective in inhibiting HIV infections.<\/jats:p>","DOI":"10.1002\/jmv.1890300411","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T18:11:49Z","timestamp":1172859109000},"page":"287-293","source":"Crossref","is-referenced-by-count":20,"title":["Antibody\u2010 and complement\u2010mediated lysis of HIV\u2010infected cells and inhibition of viral replication"],"prefix":"10.1002","volume":"30","author":[{"given":"J. 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