{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:59:51Z","timestamp":1780487991159,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":5668,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1990,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three doses of a recombinant DNA HBV vaccine (MSD) were given to healthy male homosexuals. Seventy\u2010eight out of 104 (77.6%) participants had detectable antibody (anti\u2010HBs) two months after the third dose. Seroconversion occurred in only 9 out of 27 subjects (33.3%) who were anti\u2010HIV positive compared with 69 out of 77 (89.6%) who were negative (\u03c7<jats:sup>2<\/jats:sup> = 30.8; <jats:italic>P<\/jats:italic> &lt; .001). Fifteen of the 18 anti\u2010HIV positive who did not mount an antibody response to the hepatitis B vaccine (anti\u2010HBs) later progressed to persistent generalised lymphadenopathy syndrome (5), AIDS\u2010related complex (5), and AIDS (5). Only one of the nine anti\u2010HIV positive anti\u2010HBs responders developed PGL (\u03c7<jats:sup>2<\/jats:sup> = 10.14; <jats:italic>P<\/jats:italic> &lt; .005).<\/jats:p><jats:p>Our results show that anti\u2010HIV positive homosexuals are poor responders to the recombinant hepatitis B vaccine and anti\u2010HIV positive non\u2010responders are more likely to develop clinically apparent HIV infection.<\/jats:p>","DOI":"10.1002\/jmv.1890310207","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T18:41:19Z","timestamp":1172860879000},"page":"109-111","source":"Crossref","is-referenced-by-count":40,"title":["Diminished response to recombinant hepatitis B vaccine in homosexual men with HIV antibody: An indicator of poor prognosis"],"prefix":"10.1002","volume":"31","author":[{"given":"Richard H. T.","family":"Loke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain M.","family":"Murray\u2010Lyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie J.","family":"Zuckerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6378.1621"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.8.848"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198703053161015"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90415-6"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.294.6576.866"},{"key":"e_1_2_1_7_1","first-page":"132","article-title":"Hepatitis B antigen and antibody in a male homosexual population","volume":"53","author":"Coleman JC","year":"1977","journal-title":"British Journal of Venereal Diseases"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-2-101"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91376-X"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198607243150401"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5864.455"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6476.1176"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91343-8"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840010502"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92451-2"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890310207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890310207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T10:55:43Z","timestamp":1697972143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890310207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,6]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,6]]}},"alternative-id":["10.1002\/jmv.1890310207"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890310207","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,6]]}}}