{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:57:29Z","timestamp":1698109049118},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":5576,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein\u2010Barr virus (EBV) is often associated with lethal lymphoproliferative disease in immunologically compromised individuals. Recently, we have studied a 20\u2010month\u2010old boy with X\u2010linked lymphoproliferative disease (XLP) who had succumbed to infectious mononucleosis (IM) complicated by fulminant hepatitis and virus\u2010associated hemophagocytic syndrome following EBV infection. EBV genomes were detected in peripheral blood lymphocytes (PBL), cervical and mesenteric lymph nodes, liver, spleen, thymus, and bone marrow. According to restriction endonuclease analyses, the EBV\u2010DNA pattern was similar in all samples except for the EBV\u2010DNA from the bone marrow. Additionally, circular EBV\u2010DNA (suggesting a latent infection) predominated in spontaneously established lymphoblastoid cell lines (LCLs) derived from both the lymph node and cord lymphocytes co\u2010cultured with PBL. In contrast, both circular and linear EBV\u2010DNA (suggesting a lytic infection) were noted in spontaneously established LCLs derived from his PBL. Furthermore, LCLs derived from both the lymph node and cord lymphocytes co\u2010cultured with PBL expressed fewer reactive cells for early antigen (EA) and viral capsid antigen (VCA) than spontaneous LCLs from his PBL, thus providing evidence for different B cellular susceptibility to EBV infection in this patient with XLP. Finally, defective EBV\u2010specific cytotoxic T cell activity was observed in this patient. Latent EBV infected cells may easily escape immuno\u2010surveillance by the host. These findings may explain the fatal course of EBV infection in this patient.<\/jats:p>","DOI":"10.1002\/jmv.1890320108","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T18:51:28Z","timestamp":1172861488000},"page":"47-52","source":"Crossref","is-referenced-by-count":7,"title":["Differential cellular susceptibility to Epstein\u2010Barr virus infection in a patient with X\u2010linked lymphoproliferative disease"],"prefix":"10.1002","volume":"32","author":[{"given":"Motohiko","family":"Okano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey M.","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack R.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Purtilo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.151.3.614"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(70)90523-9"},{"key":"e_1_2_1_4_1","first-page":"1","volume-title":"The Epstein\u2010Barr virus: Recent advances","author":"Epstein MA","year":"1986"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1128\/jvi.50.1.248-254.1984","article-title":"Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis","volume":"50","author":"Gardella T","year":"1984","journal-title":"Journal of Virology"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1128\/jvi.14.1.174-176.1974","article-title":"Host cell regulation of induction of Epstein\u2010Barr virus","volume":"14","author":"Glazer R","year":"1974","journal-title":"Journal of Virology"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-4-538"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90028-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-4163-5_5"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/157.2.299"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.4.589"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(90)90054-T"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.1.3.300"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00917127"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92004-8"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90803-2"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198405103101905"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198411013111806"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/272373a0"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890320108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890320108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T20:07:58Z","timestamp":1698005278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890320108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,9]]}},"alternative-id":["10.1002\/jmv.1890320108"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890320108","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,9]]}}}