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Variability of up to 1.5 kbp at both ends of the genome symmetrically was observed using restriction analysis of the DNA isolates and by Southern Blot experiments using cloned and labeled Hindlll terminal DNA fragments of MCV\u20101 prototype DNA. The variable sequences were mainly confined to the terminal fragments and parts of the MCV\u20101 terminal repeats.<\/jats:p><jats:p>Labeled probes did not detect terminal sequences of MCV Type 2 under the applied stringency. A less marked instability of the central MCV\u20101 BamHI DNA fragment F was observed within the genome coordinates 0.431 to 0.454 mu. Reiteration of tandem repeats similar to those described for vaccinia virus might explain the variability of the terminal sequences and might be involved in viral replication.<\/jats:p>","DOI":"10.1002\/jmv.1890330313","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T19:21:06Z","timestamp":1172863266000},"page":"211-217","source":"Crossref","is-referenced-by-count":21,"title":["Stability of molluscum contagiosum virus DNA among 184 patient isolates: Evidence for variability of sequences in the terminal inverted repeats"],"prefix":"10.1002","volume":"33","author":[{"given":"J. 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