{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:18:16Z","timestamp":1773886696989,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5213,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1991,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prevalence of serum HBV DNA in individuals positive for anti\u2010HBc alone was determined by the polymerase chain reaction in two groups with endemic HBV infection from Canton (group A) and Hainan (group B), provinces of China. Twenty\u2010one out of 294 individuals in group A (7.2%) and 193 out of 1995 in group B (9.7%) were positive for anti\u2010HBc but negative for other markers of ongoing or past HBV infection. (HBsAg and anti\u2010HBs). HBV DNA was detected in 6\/21 sera in group A (28.6%) and 68\/193 in group B (35.2%) in their initial serum specimen. One of the six HBV\u2010DNA\u2010positive individuals in group A became negative after 6 months and four of the 58 positive in group B became negative at 4 years of follow\u2010up. All of the individuals remained positive for anti\u2010HBc and negative for anti\u2010HBs, but one of them became positive for HBsAg on follow\u2010up. None of the anti\u2010HBc\u2010 and HBV\u2010DNA\u2010positive subjects had symptoms of liver diseases. They were, therefore, defined as chronic asymptomatic HBV carriers with undetectable HBsAg. This type of carrier should be added to the typical HBsAg\u2010positive carrier, who constitutes about 10\u201315% of the general Chinese population, to give a more complete estimate of asymptomatic HBV carriers in China.<\/jats:p>","DOI":"10.1002\/jmv.1890350112","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T20:25:25Z","timestamp":1172867125000},"page":"55-59","source":"Crossref","is-referenced-by-count":54,"title":["Hepatitis B virus DNA in sera of virus carriers positive exclusively for antibodies to the hepatitis B core antigen"],"prefix":"10.1002","volume":"35","author":[{"given":"Kang\u2010Xian","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Sen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shibo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.6.3906"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890330111"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197806222982502"},{"key":"e_1_2_1_5_1","first-page":"121","volume-title":"Viral Hepatitis","author":"Jiang YT","year":"1982"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.31.9.837"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/339237a0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1182\/blood.V73.1.17.17","article-title":"Hepatitis B virus DNA in the serum of Sardinian blood donors negative for the hepatitis B surface antigen","volume":"73","author":"Lai ME","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080411"},{"key":"e_1_2_1_10_1","first-page":"164","article-title":"Certain aspects regarding chronic sub\u2010clinical hepatitis B virus infection (in Chinese)","volume":"13","author":"Luo K\u2010X","year":"1988","journal-title":"Medical Journal of Chinese People Liberation Army"},{"key":"e_1_2_1_11_1","first-page":"404","volume-title":"Immunochemistry of Viruses, II. 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