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During the first week postin\u2010fection (pi), all animals developed acinar pancreatitis, followed by focal myocarditis. In accordance with the increasing infectivity titers, such progressive histopathological changes correlated with local viral replication. From day 4 pi, acinar degeneration accompanied by diffuse inflammatory exudate was observed in the pancreas, followed by fatty tissue replacement by day 8. In the heart, focal necrosis rather than inflammatory reaction first appeared at 4 days pi and became widespread by 6\u20138 days pi. Necrotic foci usually presented calcium deposits, with absence of myofibrils in the affected fibers. The fact that both periodic acid Schiff (PAS) and Best carmine staining remained positive even after diastase treatment ruled out basophilic necrosis. In summary, the pancreas appeared to be the site of primary viral replication leading to viremia.<\/jats:p>","DOI":"10.1002\/jmv.1890350202","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T20:22:01Z","timestamp":1172866921000},"page":"71-75","source":"Crossref","is-referenced-by-count":15,"title":["Murine acinar pancreatitis preceding necrotizing myocarditis after coxsackievirus B3 inoculation"],"prefix":"10.1002","volume":"35","author":[{"given":"Ricardo M.","family":"G\u00f3mez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo F.","family":"Lascano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eca I.","family":"Berr\u00eca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"3","article-title":"Myocarditis. 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