{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T06:10:20Z","timestamp":1698127820861},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":5089,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In contrast to lymphocytic choriomeningitis virus, another arenavirus, Junin virus (JV), the etiologic agent of Argentine hemorrhagic fever, when inoculated into suckling mice, induces lethal meningoencephalitis characterized by a delayed\u2010type hypersensitivity (DTH)\u2010like immune response. However, the adult BALB\/c mouse is resistant to infection and no DTH reaction can be seen. This different viral sensitivity may be related t o the development of an antigen non\u2010specific DTH\u2010suppressor cell pathway at work in the adult mouse. When the resistant mice are treated with cyclophosphamide (Cy) (50 mg\/kg each dose) given at days \u22121,+1,+4 (zero: infection day), animals become susceptible and develop DTH reaction in brain that leads to death. We analyze the influence of the timing of Cy administration on the suppressor system developing after infection. It was found that Cy depletes the previously described JV\u2010induced suppressor populations (Tsv) but a new suppressor cell (Tsv<jats:sup>*<\/jats:sup>) is disclosed bearing the Thy 1 <jats:sup>+<\/jats:sup> Ly1<jats:sup>+<\/jats:sup>2<jats:sup>\u2212<\/jats:sup> phenotype which is unable to depress DTH in Cy\u2010treated animals. With only two doses of Cy corresponding to days \u22121 and + 1, the target of Tsv<jats:sup>*<\/jats:sup> cells is depleted but the third dose is still required to achieve full depletion of Tsv cells which are able to employ the Cy\u2010resistant antigen\u2010specific suppressor cells as targets. Since the Cy treatment is able t o deplete the Tsv population together with the target of Tsv<jats:sup>*<\/jats:sup> cells, animals became unable to regulate lethal DTH reaction. Thus, a cellular explanation for an empirically established Cy schedule able to abrogate the adult mouse resistance to JV is proposed.<\/jats:p>","DOI":"10.1002\/jmv.1890360107","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T21:12:47Z","timestamp":1172869967000},"page":"32-38","source":"Crossref","is-referenced-by-count":1,"title":["Correlation between cyclophosphamide\u2010induced viral susceptibility and depletion of junin virus\u2014induced suppressor populations"],"prefix":"10.1002","volume":"36","author":[{"given":"Oscar E.","family":"Campetella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora V.","family":"Galassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hebe A.","family":"Barrios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01309923"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890250213"},{"key":"e_1_2_1_4_1","first-page":"407","article-title":"Suppressor T cell population induced by Junin virus in adult mice","volume":"64","author":"Campetella OE","year":"1988","journal-title":"Immunology"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890260412"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890300308"},{"key":"e_1_2_1_7_1","unstructured":"CampetellaOE GalassiNV BarriosHA(1991):Junin virus\u2013induced non\u2013specific suppressor cells interact with unrelated antigen\u2013specific suppressor cells. Immunology (in press)."},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4049\/jimmunol.132.1.95","article-title":"Inhibition of the development of suppressor cells in culture by 4\u2013hydroperoxycyclophosphamide","volume":"132","author":"Cowens JW","year":"1984","journal-title":"Journal of Immunology"},{"key":"e_1_2_1_9_1","first-page":"259","article-title":"Self destructive DTH response in Junin virus infected newborn mice","volume":"1","author":"Giovanniello OA","year":"1983","journal-title":"Comunicaciones Biologicas"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-67-10-2103"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(86)90271-6"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.4049\/jimmunol.125.3.1104","article-title":"Relative susceptibilities of T cell subsets involved in delayed\u2013type hypersensitivity to sheep red blood cells to the in vitro action of 4\u2013hydroperoxicy\u2013clophosphamide","volume":"125","author":"Kaufmann SHE","year":"1980","journal-title":"Journal of Immunology"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1986.tb02078.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072022"},{"key":"e_1_2_1_15_1","first-page":"61","article-title":"Further experiments on the action of antithymocyte serum in experimental Junin virus infection","volume":"20","author":"Nota NR","year":"1976","journal-title":"Acta Virologica"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.4049\/jimmunol.130.4.1600","article-title":"Effect of fractional cyelophosphamide dosage on sheep red blood cells\u2013delayed\u2013type hypersensitivity response in mice","volume":"130","author":"Rondinone SN","year":"1983","journal-title":"Journal of Immunology"},{"key":"e_1_2_1_17_1","first-page":"211","article-title":"Circuito supresor de la hipersensibilidad mediada por c\u00e9lulas en el modelo rat\u00f3n\u2013gl\u00f3bulos rojos de carnero","volume":"28","author":"Rondinone SN","year":"1986","journal-title":"Revista Latinoamericana de Microbiologia"},{"key":"e_1_2_1_18_1","first-page":"260","article-title":"Abrogation of Junin virus encephalitis by critical cyelophosphamide timing and dosage","volume":"31","author":"Rondinone SN","year":"1987","journal-title":"Acta Virologica"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.4049\/jimmunol.134.5.2889","article-title":"Delayed hypersensitivity and immune protection against Herpes Simplex virus: suppressor T cells that regulate the induction of delayed hypersensitivity effector cells also regulates the induction of protective T cells","volume":"134","author":"Schrier RD","year":"1985","journal-title":"Journal of Immunology"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1986.tb02079.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000149330"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890360107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890360107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T21:25:05Z","timestamp":1698096305000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890360107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1002\/jmv.1890360107"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890360107","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}