{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:47:24Z","timestamp":1761630444635},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":5089,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The early activation of T\u2010 and B\u2010cell responses to cytomegalovirus was studied in immunosuppressed patients. Primary lymphocyte stimulation to cytomegalovirus (CMV) antigen, a measure of T\u2010helper activity, and anti\u2010CMV IgG subclass responses were analyzed. Ten patients suffering from primary CMV infection following renal transplantation were studied. Of the ten, nine became positive for CMV induced lymphocyte proliferation 5\u201040 weeks after transplantation. Nine showed an almost simultaneous appearance of anti\u2010CMV IgG1 and three at 3\u201032 weeks after transplantation, while one patient synthesized only low levels of anti\u2010CMV IgG1. The lymphocyte proliferation assays have limited diagnostic value for primary CMV infection in renal transplant patients. The humoral and cellular immune responses seemed to be independent of each other.<\/jats:p>","DOI":"10.1002\/jmv.1890360113","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T21:12:47Z","timestamp":1172869967000},"page":"65-69","source":"Crossref","is-referenced-by-count":14,"title":["Immunoglobulin G subclasses and lymphocyte stimulatory responses to cytomegalovirus in transplant patients with primary cytomegalovirus infections"],"prefix":"10.1002","volume":"36","author":[{"given":"T.","family":"Mathiesen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Brattstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Linde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ljungman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Wahren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90685-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1128\/iai.42.1.237-244.1983","article-title":"Virus specific antibody activity of different subclasses of immunoglobulins G and A in cytomegalovirus infection","volume":"42","author":"Linde A","year":"1983","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1128\/iai.22.1.176-180.1978","article-title":"Cellular immune response to cytomegalovirus infection after renal transplantation","volume":"22","author":"Linnemann CC","year":"1978","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1182\/blood.V68.1.108.108","article-title":"Cytomegalovirus\u2010specific lymphocyte proliferation and in vitro cytomegalovirus IgG synthesis for diagnosis of cytomegalovirus infections after bone marrow transplantation","volume":"68","author":"Ljungman P","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(85)90130-2"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890250104"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/142.6.816"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/153.3.478"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1982.tb01054.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1128\/iai.13.6.1633-1637.1976","article-title":"Cytomegalovirus infection and immunity in renal allograft recipients: assessment of the competence of humoral immunity","volume":"13","author":"Rytel MW","year":"1976","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1988.tb00741.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/142.1.102"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(81)90029-X"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198411000-00007"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890360113","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890360113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T21:25:21Z","timestamp":1698096321000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890360113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1002\/jmv.1890360113"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890360113","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}