{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:09:47Z","timestamp":1761487787514},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4998,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A hepatitis B vaccination campaign was carried out in a town of 60,000 inhabitants, Afragola, Campania, Italy, a hyperendemic area for hepatitis B where HBsAg prevalence was 13.4% and anti\u2010HBc prevalence was 64.7%. This experimental pilot project aimed to reduce the incidence of both acute and asymptomatic viral hepatitis B and of related chronic liver complications. From 1983\u20101989, 8,400 subjects were vaccinated: 6,900 children up to 10 years of age and 1,500 subjects from 11\u201060 years of age. High seroconversion rates were observed: 99.0% in all children under one year of age, 96.0% in the older children, and 86.7% in adults. The rate of infection in Afragola has diminished from 63\/100,000 in 1983 to 10\/100,000 in 1989. Carriers of HbsAg decreased in the general population (7.3% com\u2010 pared to 13.4%). especially in children up to 10 years of age (1.0 compared to 9.0%). In babies who received hepatitis B vaccine at the same time as compulsory vaccinations compliance was 98% while it was 80% in babies who were vaccinated separately.<\/jats:p><jats:p>In June 1991 the Italian Parliament promulgated a decree which imposes hepatitis B vaccination for all newborn babies at 3, 5, and 1 1months of age, at the same times as the mandatory childhood accinations (diphtheria, tetanus, and polio) according t o a new protocol (Piazza scheme) which has been in use since January 1987 in our pilot vaccination campaign in Afragola.<\/jats:p>","DOI":"10.1002\/jmv.1890360408","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T21:04:51Z","timestamp":1172869491000},"page":"274-278","source":"Crossref","is-referenced-by-count":18,"title":["A pilot model of vaccination against hepatitis B virus suitable for mass vaccination campaigns in hyperendemic areas"],"prefix":"10.1002","volume":"36","author":[{"given":"G.","family":"da Villa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Piazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Lorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Picciotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Peluso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Deluca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Basile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Anonymous (1991):Obbligatoriet\u00e0 della vaccinazione contro l'epatite B. Legge n. 165 27 Maggio 1991. Gazzetta Ufficiale della Repubblica Italiana 1 Giugno 1991 pp3\u20134."},{"key":"e_1_2_1_3_1","first-page":"71","article-title":"Prevalenza di casi con positivit\u00e0 nel siero dell'antigene Australia HBsAg in alcuni campioni di popolazione in Campania. I. Rilevazioni sulla popolazione di Afragola","volume":"3","author":"Da Villa G","year":"1978","journal-title":"Igiene Moderna"},{"key":"e_1_2_1_4_1","first-page":"96","article-title":"HBsAg carriers among blood donors in Italy: a retrospective survey of data from 189 blood banks","volume":"28","author":"Giusti G","year":"1981","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/oxfordjournals.aje.a113680","article-title":"Prevalence of hepatitis B markers in Italy","volume":"48","author":"Pasquini P","year":"1983","journal-title":"American Journal of Epidemiology"},{"key":"e_1_2_1_6_1","unstructured":"PiazzaM(1990):Epatite virale acuta e cronica. 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