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Scatchard analysis revealed a single class binding site of Kd 104 \u00b1 27 nM\/I and 5.4 \u00b1 1.2 \u00d7 10<jats:sup>5<\/jats:sup>sites per cell. Competition of HBV with pre\u2010S1 peptides was dose dependent, and demonstrated it as the dominant binding site. In view of the suggested sequence homology between the peptide and IgA, cross\u2010competition studies were carried out. The results indicate no direct role of IgA receptor in HBV binding. 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